Ishida Hideyuki, Akita Hirofumi, Watanabe Yasunori, Nakaguchi Kazunori, Kabuto Toshiyuki
Dept. of Surgery, Osaka Seamen's Insurance Hospital.
Gan To Kagaku Ryoho. 2006 Jun;33(6):817-9.
We report the complete response for one year of a patient with simultaneous multiple lung metastases from colon cancer who was treated using a combination of irinotecan (CPT-11) and uracil/tegafur (UFT)/Leucovorin (LV) using a schedule reported overseas. A 61-year-old woman was admitted to our hospital and diagnosed with ascending colon cancer and simultaneous multiple lung metastases. The patient underwent a right hemicolectomy and was treated with CPT-11 (150 mg/m(2)) on day 1 and oral UFT and oral LV on days 1-14. This treatment cycle was repeated every 3 weeks. A CT examination after 4 cycles of chemotherapy revealed a partial response of multiple lung metastases, and the next examination after 6 cycles revealed a complete response. The adverse effects observed during this chemotherapy regimen were leucopenia (grade 1), neutropenia (grade 2), vomiting (grade 2) and hair loss (grade 1). The patient is now receiving her 22nd cycle of chemotherapy, and her multiple metastases have shown a complete response for one year. The CPT-11 and UFT/LV combination therapy was well tolerated and was covered by the national health insurance system in Japan. This treatment may enable prolonged survival and improve quality of life in patients with metastatic colorectal cancer.
我们报告了一名患有同时性多发肺转移结肠癌患者，按照海外报道的方案使用伊立替康（CPT-11）、尿嘧啶/替加氟（UFT）/亚叶酸钙（LV）联合治疗一年后达到完全缓解的病例。一名61岁女性因升结肠癌并同时性多发肺转移入院。患者接受了右半结肠切除术，并于第1天接受CPT-11（150mg/m²）治疗，第1 - 14天接受口服UFT和口服LV治疗。每3周重复此治疗周期。化疗4周期后的CT检查显示多发肺转移部分缓解，6周期后的下一次检查显示完全缓解。该化疗方案期间观察到的不良反应为白细胞减少（1级）、中性粒细胞减少（2级）、呕吐（2级）和脱发（1级）。患者目前正在接受第22周期化疗，其多发转移灶已完全缓解一年。CPT-11与UFT/LV联合治疗耐受性良好，且在日本被纳入国家医疗保险体系。这种治疗可能使转移性结直肠癌患者延长生存期并改善生活质量。
