Görlinger S, Kooistra H S, van den Broek A, Okkens A C
Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, University of Utrecht, The Netherlands.
J Vet Intern Med. 2002 Nov-Dec;16(6):710-3. doi: 10.1892/0891-6640(2002)016<0710:tofhic>2.3.co;2.
Fibroadenomatous hyperplasia (FAH) is characterized by a rapid proliferation of mammary stroma and duct epithelium of 1 or more glands and predominantly affects younger female cats. Endogenous progesterone and exogenous progestogens play an important role in the genesis of FAH. The presence of progesterone receptors in fibroadenomatous tissue allows for targeted endocrine therapy with progesterone receptor blockers. We report on 22 young cats with FAH, none of which had responded to the withdrawal of progestogens or ovariectomy. The common signs were tachycardia (11 cats); skin ulceration, painful mammary glands, or both (16 cats); lethargy (8 cats); and anorexia (4 cats). The cats were treated with subcutaneous injections of the progesterone receptor blocker aglépristone on 1 (7 cats, 20 mg/kg) or 2 consecutive days (15 cats, 10 mg/kg/d) once weekly. All but 1 cat responded with a complete and lasting remission of signs after 1-4 weeks of treatment. Two cats had a short-term skin irritation at the site of the aglépristone injection. Two pregnant cats with FAH aborted after treatment with aglépristone and subsequently developed endometritis. In conclusion, the results of this study demonstrate that FAH in cats can be treated successfully with the progesterone receptor blocker aglépristone.
纤维腺瘤样增生（FAH）的特征是一个或多个腺体的乳腺基质和导管上皮快速增殖，主要影响年轻母猫。内源性孕酮和外源性孕激素在FAH的发生中起重要作用。纤维腺瘤样组织中孕酮受体的存在使得可以使用孕酮受体阻滞剂进行靶向内分泌治疗。我们报告了22只患有FAH的年轻猫，其中没有一只对停用孕激素或卵巢切除术有反应。常见症状有心动过速（11只猫）；皮肤溃疡、乳腺疼痛或两者皆有（16只猫）；嗜睡（8只猫）；以及厌食（4只猫）。这些猫每周皮下注射一次孕酮受体阻滞剂阿格列司酮，连续1天（7只猫，20mg/kg）或连续2天（15只猫，10mg/kg/天）。除1只猫外，所有猫在治疗1-4周后症状完全且持久缓解。2只猫在阿格列司酮注射部位出现短期皮肤刺激。2只患有FAH的怀孕猫在接受阿格列司酮治疗后流产，随后发生子宫内膜炎。总之，本研究结果表明，猫的FAH可以用孕酮受体阻滞剂阿格列司酮成功治疗。
