Basoglu Abdullah, Sevinc Mutlu, Birdane Fatih M, Boydak Murat
Department of Internal Medicine, Faculty of Veterinary Medicine, Selcuk University, Konya, Turkey.
J Vet Intern Med. 2002 Nov-Dec;16(6):732-5. doi: 10.1892/0891-6640(2002)016<0732:eosbit>2.3.co;2.
The effects of sodium borate (100 mg/kg body weight, p.o., 15 days) from a month before expected calving until a month after calving were evaluated in dairy cows susceptible to fatty liver. Cows received either sodium borate (n = 13) or no treatment (n = 10). All cows had mild fatty livers and increased plasma triglycerides and very low density lipoprotein (VLDL) concentrations at the beginning of the experiment. The control group of cows developed significant fatty liver after calving, and 2 of them had severe fatty liver associated with clinical and biochemical abnormalities. There were no clinicopathological signs related to sodium borate administration. Serum triglycerides and VLDL concentrations before calving decreased significantly at calving and after calving in controls, and they were within the normal range only after calving. There were significant alterations during the experiment in some hematological and chemical variables between groups, within period, but they were within the normal range. Unlike treated cows, serum triglycerides and VLDL concentrations correlated with liver fat content after calving in untreated cows. Our results document that sodium borate decreases the degree of fatty liver in dairy cows during early lactation.
在易患脂肪肝的奶牛中，评估了从预期产犊前一个月到产犊后一个月口服硼酸钠（100毫克/千克体重，持续15天）的效果。奶牛被分为两组，一组接受硼酸钠治疗（n = 13），另一组不接受治疗（n = 10）。在实验开始时，所有奶牛均有轻度脂肪肝，血浆甘油三酯和极低密度脂蛋白（VLDL）浓度升高。对照组奶牛在产犊后出现了明显的脂肪肝，其中2头患有严重脂肪肝，并伴有临床和生化异常。未观察到与硼酸钠给药相关的临床病理体征。对照组奶牛在产犊时和产犊后血清甘油三酯和VLDL浓度显著下降，仅在产犊后处于正常范围内。实验期间，两组之间以及同一组内的一些血液学和化学变量存在显著变化，但均在正常范围内。与接受治疗的奶牛不同，未接受治疗的奶牛在产犊后血清甘油三酯和VLDL浓度与肝脏脂肪含量相关。我们的结果表明，硼酸钠可降低奶牛早期泌乳期间的脂肪肝程度。
