鞘氨醇菌素F的全合成。

Total synthesis of sphingofungin F.

作者信息

Lee Kee-Young, Oh Chang-Young, Ham Won-Hun

机构信息

College of Pharmacy, SungKyunKwan University, Suwon 440-746, Korea.

出版信息

Org Lett. 2002 Dec 12;4(25):4403-5. doi: 10.1021/ol020164f.

DOI:10.1021/ol020164f

PMID:12465898

Abstract

[reaction: see text] A concise, stereocontrolled synthesis of sphingofungin F was achieved. Key features involve diastereoselective oxazoline formation catalyzed by palladium(0), MgBr(2)-promoted gamma-alkoxy allylic stannane addition, and palladium(0)-catalyzed coupling of a vinyl iodide with an organozinc reagent.

摘要

[反应：见正文] 实现了鞘氨醇菌素F的简洁、立体控制合成。关键特征包括钯(0)催化的非对映选择性恶唑啉形成、MgBr(2)促进的γ-烷氧基烯丙基锡烷加成以及钯(0)催化的乙烯基碘与有机锌试剂的偶联。