Greenwell Henry, Bissada Nabil F
Periodontics, School of Dentistry, University of Louisville, Louisville, Kentucky, USA.
Drugs. 2002;62(18):2581-7. doi: 10.2165/00003495-200262180-00002.
Conventional periodontal therapy consists of mechanical scaling and root planing, and surgical treatment. This is still the mainstay of periodontal treatment. Adjunctive antimicrobial treatments, both systemic and local delivery, are becoming more sophisticated and useful in the treatment of recurrent periodontitis. Also very promising are adjunctive treatments that modulate the host response and decrease levels of destructive pro-inflammatory cytokines or matrix metalloproteinases. Smoking is a major risk factor for periodontitis and has a profound impact on the progression of periodontal bone and attachment loss. In the interest of improved periodontal health patients should be encouraged to stop smoking. Finally bacterial endotoxins that stimulate the release of pro-inflammatory cytokines can have systemic effects and may lead to pre-term, low birthweight babies, and cardiovascular diseases such as atherosclerosis, myocardial infarction and stroke. Health professionals need to be cognisant of the effect dental health can have on systemic diseases and refer for treatment when appropriate to ensure that optimum oral and systemic health is achieved for their patients.
传统的牙周治疗包括机械洁治和根面平整以及手术治疗。这仍然是牙周治疗的主要手段。辅助性抗菌治疗,包括全身给药和局部给药,在复发性牙周炎的治疗中变得越来越成熟且有效。调节宿主反应并降低破坏性促炎细胞因子或基质金属蛋白酶水平的辅助治疗也非常有前景。吸烟是牙周炎的主要危险因素,对牙周骨丧失和附着丧失的进展有深远影响。为了改善牙周健康,应鼓励患者戒烟。最后,刺激促炎细胞因子释放的细菌内毒素可产生全身影响,并可能导致早产、低体重儿以及动脉粥样硬化、心肌梗死和中风等心血管疾病。卫生专业人员需要认识到牙齿健康对全身疾病的影响,并在适当时转诊进行治疗,以确保为患者实现最佳的口腔和全身健康。