与5-氟尿嘧啶相关的胆小管鳞状化生：一例临床病理病例报告
Squamous metaplasia of the canaliculi associated with 5-fluorouracil: a clinicopathologic case report.
作者信息
Agarwal Madhu R, Esmaeli Bita, Burnstine Michael A
机构信息
Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
出版信息
Ophthalmology. 2002 Dec;109(12):2359-61. doi: 10.1016/s0161-6420(02)01290-3.
OBJECTIVE
To illustrate a newly recognized histopathologic change in a patient with canalicular obstruction after weekly administration of 5-fluorouracil for colon cancer.
DESIGN
Interventional case report.
METHODS
A full-thickness section of canaliculus was obtained during surgical repair.
MAIN OUTCOME MEASURE
Histopathologic changes in the specimen.
RESULTS
The prominent histologic feature of the canalicular specimen was severe squamous metaplasia with narrowing of the lumen.
CONCLUSION
Canalicular obstruction may follow systemic use of 5-fluorouracil due to squamous metaplasia.
目的
阐述一名结肠癌患者在每周接受5-氟尿嘧啶治疗后出现小胆管阻塞时新发现的组织病理学变化。
设计
介入性病例报告。
方法
在手术修复过程中获取小胆管全层切片。
主要观察指标
标本的组织病理学变化。
结果
小胆管标本的显著组织学特征为严重的鳞状化生伴管腔狭窄。
结论
由于鳞状化生，全身使用5-氟尿嘧啶可能导致小胆管阻塞。
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