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通过在膜中用麦角甾醇替代胆固醇来改变红细胞（见文章）-ATP酶。

Alteration of erythrocyte (see article) -ATPase by replacement of cholesterol by desmosterol in the membrane.

作者信息

Fiehn W, Seiler D

出版信息

Experientia. 1975 Jul 15;31(7):773-5. doi: 10.1007/BF01938456.

DOI:10.1007/BF01938456
PMID:124662
Abstract

Cholesterol of red blood cells (RBC) is readily exchanged by desmosterol and vice versa. The resulting alteration in the sterol composition influences the specific (Na+ plus K+)-ATPase activity. It is suggested that this effect is due to an altered membrane fluidity.

摘要

红细胞（RBC）中的胆固醇很容易与去氢胆固醇相互交换，反之亦然。由此产生的固醇组成变化会影响特定的（钠加钾）-ATP酶活性。有人认为这种效应是由于膜流动性改变所致。

相似文献

1
Alteration of erythrocyte (see article) -ATPase by replacement of cholesterol by desmosterol in the membrane.通过在膜中用麦角甾醇替代胆固醇来改变红细胞（见文章）-ATP酶。
Experientia. 1975 Jul 15;31(7):773-5. doi: 10.1007/BF01938456.
2
Myotonia induced by diazacholesterol: increased (Na+ + K+)-ATPase activity of erythrocyte ghosts and development of cataracts.
Exp Neurol. 1973 Dec;41(3):738-44. doi: 10.1016/0014-4886(73)90064-2.
3
Myotonia induced by single doses of 20, 25 diazacholesterol: increased muscle and plasma desmosterol levels, unaltered (Na+ + K+)-ATPase activity of erythrocyte ghosts.
Biochem Med. 1975 Aug;13(4):307-11. doi: 10.1016/0006-2944(75)90169-6.
4
ATPases of erythrocytes from rats with 20, 25-diazacholesterol induced myotonia.
FEBS Lett. 1973 Aug 15;34(2):163-4. doi: 10.1016/0014-5793(73)80783-5.
5
[Effect of sterol composition on the activity of transport-ATPase of the erythrocyte membrane].[固醇成分对红细胞膜转运ATP酶活性的影响]
Verh Dtsch Ges Inn Med. 1975;81:835-7.
6
Membrane fluidity, cholesterol and allosteric transitions of membrane-bound Mg2+-ATPase, (Na+ + K+)-ATPase and acetylcholinesterase from rat erythrocytes.
FEBS Lett. 1973 Dec 15;38(1):101-5. doi: 10.1016/0014-5793(73)80523-x.
7
Effect of cholesterol oxidation on (Na+, K+) ATPase activity of erythrocyte membranes.
Experientia. 1976;32(7):849-50. doi: 10.1007/BF02003723.
8
Influence of altered sterol composition on (Na+, K+) ATPase activity of cardiac sarcolemma.
Experientia. 1974 Dec 15;30(12):1421-2. doi: 10.1007/BF01919672.
9
Functional organization of the partial reactions of Na plus and K plus-activated ATPase within the red cell membrane.红细胞膜内钠钾激活的ATP酶部分反应的功能组织
Biochem Biophys Res Commun. 1969 Aug 15;36(4):631-8. doi: 10.1016/0006-291x(69)90352-0.
10
The effect of a high cholesterol diet on 20,25-diazacholesterol-induced myotonia.
Exp Neurol. 1975 Nov;49(2):429-38. doi: 10.1016/0014-4886(75)90099-0.

引用本文的文献

1
Effects of different sterols on the inhibition of cell culture growth caused by the growth retardant tetcyclacis.不同甾醇对生长抑制剂四氯环丙烯抑制细胞培养生长的影响。
Planta. 1985 Jun;164(3):370-5. doi: 10.1007/BF00402948.
2
The diversity of marine sterols and the role of algal bio-masses; from facts to hypothesis.海洋甾醇的多样性及藻类生物质的作用：从事实到假说
Experientia. 1979 Dec 15;35(12):1541-3. doi: 10.1007/BF01953179.
3
Effect of cholesterol oxidation on (Na+, K+) ATPase activity of erythrocyte membranes.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
The origin of plasma cholesterol and the rates of equilibration of liver, plasma, and erythrocyte cholesterol.血浆胆固醇的来源以及肝脏、血浆和红细胞胆固醇的平衡速率。
J Lab Clin Med. 1955 Sep;46(3):359-71.
3
The effect of partial replacements of membrane cholesterol by other steroids on the osmotic fragility and glycerol permeability of erythrocytes.其他类固醇对红细胞渗透脆性和甘油通透性的影响，通过部分替代膜胆固醇来实现。
Experientia. 1976;32(7):849-50. doi: 10.1007/BF02003723.
Biochim Biophys Acta. 1969 Jul 15;183(2):334-45. doi: 10.1016/0005-2736(69)90089-3.
4
Studies on lecithin-cholesterol-water interactions by differential scanning calorimetry and X-ray diffraction.通过差示扫描量热法和X射线衍射对卵磷脂-胆固醇-水相互作用的研究。
Biochim Biophys Acta. 1968 Apr 29;150(3):333-40. doi: 10.1016/0005-2736(68)90132-6.
5
A spin label study of sarcoplasmic vesicles.
Eur J Biochem. 1971 Jul 15;21(1):17-21. doi: 10.1111/j.1432-1033.1971.tb01434.x.
6
Influence of temperature acclimatization on the temperature-dependence and ouabain-sensitizing of goldfish intestinal adenosine triphosphatase.温度驯化对金鱼肠道三磷酸腺苷酶的温度依赖性和哇巴因敏感性的影响。
Biochem J. 1967 Oct;105(1):65-71. doi: 10.1042/bj1050065.
7
Influence of altered sterol composition on (Na+, K+) ATPase activity of cardiac sarcolemma.
Experientia. 1974 Dec 15;30(12):1421-2. doi: 10.1007/BF01919672.
8
ATPases of erythrocytes from rats with 20, 25-diazacholesterol induced myotonia.
FEBS Lett. 1973 Aug 15;34(2):163-4. doi: 10.1016/0014-5793(73)80783-5.
9
The role of lipid-phase transitions in the regulation of the (sodium + potassium) adenosine triphosphatase.
Biochemistry. 1973 Jul 3;12(14):2635-7. doi: 10.1021/bi00738a013.
10
Diazacholesterol myotonia: accumulation of desmosterol and increased adenosine triphosphatase activity of sarcolemma.二氮杂胆固醇性肌强直：羊毛甾醇蓄积与肌膜三磷酸腺苷酶活性增加
Science. 1973 Mar 2;179(4076):910-2. doi: 10.1126/science.179.4076.910.