二氮杂胆固醇性肌强直：羊毛甾醇蓄积与肌膜三磷酸腺苷酶活性增加

Diazacholesterol myotonia: accumulation of desmosterol and increased adenosine triphosphatase activity of sarcolemma.

作者信息

Peter J B, Fiehn W

出版信息

Science. 1973 Mar 2;179(4076):910-2. doi: 10.1126/science.179.4076.910.

DOI:10.1126/science.179.4076.910

Abstract

Myotonia induced in rats by 20,25-diazacholesterol is accompanied by accumulation of desmosterol in serum, fragmented sarcoplasmic reticulum, and sarcolemma. Activities of (Na(+),K(+))- and Ca(2+)-stimulated adenosine triphosphatases of the sarcolemma are increased, but not the Mg(2+)-stimulated adenosine triphosphatase. The altered sterol composition of the sarcolemma may cause this type of myotonia by decreasing the chloride conductance of the membrane.

摘要

20,25-二氮杂胆固醇在大鼠中诱导的肌强直伴随着血清中胆甾烯醇的积累、肌浆网碎片化和肌膜改变。肌膜上（Na⁺，K⁺）-和Ca²⁺刺激的三磷酸腺苷酶的活性增加，但Mg²⁺刺激的三磷酸腺苷酶活性未增加。肌膜中甾醇组成的改变可能通过降低膜的氯电导而导致这种类型的肌强直。