Hernández Edith C, Suárez Carlos F, Méndez Jairo A, Echeverry Sandra J, Murillo Luis A, Patarroyo Manuel E
Fundación Instituto de Inmunología de Colombia (FIDIC), Bogotá, Colombia.
Immunogenetics. 2002 Dec;54(9):645-53. doi: 10.1007/s00251-002-0512-2. Epub 2002 Nov 14.
Non-human primates could prove to be suitable models for the study of infectious diseases such as malaria, tuberculosis, and hepatitis; the molecules of their immune systems are in the process of being fully characterized. Due to the relevance of cytokines in the modulation of the immune response, a molecular analysis of these proteins in non-human primates from the Aotus genus was carried out. Peripheral blood mononuclear cells from four species of Aotusmonkey were obtained and their mRNAs for interleukin-2 (IL-2), IL-4, IL-6, IL-10, interferon-gamma (IFN), and tumor necrosis factor (TNF)-alpha were characterized. This study shows a high degree of conservation between nucleotide and amino acid sequences of cytokines from different Aotus species and those from humans. The TNF-alpha molecules were identical in amino acid sequences for both.
非人类灵长类动物可能被证明是研究疟疾、结核病和肝炎等传染病的合适模型；它们免疫系统的分子正处于被全面表征的过程中。由于细胞因子在免疫反应调节中的相关性，对夜猴属非人类灵长类动物中的这些蛋白质进行了分子分析。获取了四种夜猴外周血单个核细胞，并对其白细胞介素-2（IL-2）、IL-4、IL-6、IL-10、干扰素-γ（IFN）和肿瘤坏死因子（TNF）-α的信使核糖核酸进行了表征。这项研究表明，不同夜猴物种与人类细胞因子的核苷酸和氨基酸序列之间具有高度保守性。两种夜猴的TNF-α分子氨基酸序列相同。
