Yoder Jeffrey A, Mueller M Gail, Nichols Krista M, Ristow Sandra S, Thorgaard Gary H, Ota Tatsuya, Litman Gary W
Immunology Program, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA.
Immunogenetics. 2002 Dec;54(9):662-70. doi: 10.1007/s00251-002-0511-3. Epub 2002 Nov 16.
Novel immune-type receptor ( NITR) genes that encode two extracellular immunoglobulin domains and cytoplasmic immunoreceptor tyrosine-based inhibition motifs (ITIMs) have been described previously in three lineages of bony fish. In the current study, four ITIM-containing NITR cDNAs are identified in the rainbow trout ( Oncorhynchus mykiss), and their expression patterns and genomic complexity are characterized. The ITIM-containing NITR2 gene maps 1.3 cM from an ITIM-containing C-type lectin receptor ( TCL-2) on linkage group XXI. A comprehensive, phylogenetic analysis of NITRs from rainbow trout and three other major lineages of bony fish defines conserved families of NITRs and suggests an ancient lineage of distinct groups of genes. Several probable scenarios that explain the origins of variant forms of NITRs are described.
先前已在三种硬骨鱼谱系中描述了编码两个细胞外免疫球蛋白结构域和基于细胞质免疫受体酪氨酸的抑制基序（ITIM）的新型免疫型受体（NITR）基因。在本研究中，在虹鳟（Oncorhynchus mykiss）中鉴定出四个含ITIM的NITR cDNA，并对其表达模式和基因组复杂性进行了表征。含ITIM的NITR2基因在连锁群XXI上与含ITIM的C型凝集素受体（TCL-2）相距1.3厘摩。对虹鳟和其他三种主要硬骨鱼谱系的NITR进行的全面系统发育分析定义了NITR的保守家族，并提示了一个古老的不同基因群谱系。描述了几种可能解释NITR变体形式起源的情况。
