Takano C C, Girão M J B C, Sartori M G F, Castro R A, Arruda R M, Simões M J, Baracat E C, Rodrigues de Lima G
Federal University of São Paulo, São Paulo, Brazil.
Int Urogynecol J Pelvic Floor Dysfunct. 2002 Nov;13(6):342-5; discussion 345. doi: 10.1007/s001920200076.
Our objective was to compare the amount of collagen in parametrium and vaginal apex between women with uterine prolapse at pre- and postmenopause, and in women without prolapse. The study included 22 premenopausal women without prolapse (group A), 10 premenopausal women with prolapse (group B), and 23 postmenopausal women with prolapse (group C) (total 55). Patients in group A underwent abdominal hysterectomy for uterine leiomyoma, and patients in groups B and C underwent vaginal hysterectomy. During the surgical procedure we obtained biopsies from the lateral parametrium and vaginal apex. The tissue was stained for histological analysis with picrosirius. We observed a lower amount of collagen in the parametrium of women with uterine prolapse, both in menacme and in postmenopause, than in the parametrium of women without prolapse. We observed no statistically significant difference in vaginal apex between the groups.
我们的目的是比较绝经前和绝经后子宫脱垂女性与无脱垂女性的宫旁组织和阴道顶端的胶原蛋白含量。该研究纳入了22名未绝经的无脱垂女性（A组）、10名未绝经的脱垂女性（B组）和23名绝经后的脱垂女性（C组）（共55名）。A组患者因子宫平滑肌瘤接受腹式子宫切除术，B组和C组患者接受阴式子宫切除术。在手术过程中，我们从宫旁组织外侧和阴道顶端获取活检组织。组织用天狼星红染色进行组织学分析。我们观察到，无论是在绝经前还是绝经后，子宫脱垂女性宫旁组织中的胶原蛋白含量均低于无脱垂女性。我们观察到各组之间阴道顶端的差异无统计学意义。
