Span Paul N, Manders Peggy, Heuvel Joop J, Thomas Chris M G, Bosch Remko R, Beex Louk V A M, Sweep C G J
Department of Chemical Endocrinology, University Medical Center Nijmegen, Nijmegen, The Netherlands.
Oncogene. 2002 Dec 5;21(55):8506-9. doi: 10.1038/sj.onc.1206040.
The transcription factor Ets-1 regulates the expression of several angiogenic and extracellular matrix remodeling factors, and might be implicated in disease progression of breast cancer. In the present study, the prognostic value of Ets-1 expression was assessed by quantitative real-time fluorescence RT-PCR in 123 sporadic primary breast cancer samples of patients with a median follow-up time of 62 months. Ets-1 expression levels correlated significantly with VEGF and PAI-1 in the same tissue. In univariate (P=0.0011) and multivariate (P=0.005) analyses, Ets-1 expression showed significant prognostic value for relapse-free survival. Ets-1 is a strong, independent predictor of poor prognosis in breast cancer. This seems - at least in part - to be attributable to its role in transcriptional regulation of factors involved in angiogenesis (VEGF), and extracellular matrix remodeling (PAI-1).
转录因子Ets-1可调节多种血管生成因子和细胞外基质重塑因子的表达，可能与乳腺癌的疾病进展有关。在本研究中，采用定量实时荧光逆转录聚合酶链反应（RT-PCR）对123例散发性原发性乳腺癌样本进行检测，评估Ets-1表达的预后价值，这些患者的中位随访时间为62个月。在同一组织中，Ets-1表达水平与血管内皮生长因子（VEGF）和纤溶酶原激活物抑制剂-1（PAI-1）显著相关。在单因素分析（P=0.0011）和多因素分析（P=0.005）中，Ets-1表达对无复发生存具有显著的预后价值。Ets-1是乳腺癌预后不良的一个强有力的独立预测因子。这似乎至少部分归因于它在血管生成相关因子（VEGF）和细胞外基质重塑相关因子（PAI-1）转录调控中的作用。
