Cheng Qingyu, Wu Yupeng, Xia Honghai, Song Xiaoyuan
Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, China.
Department of Biochemistry and Molecular Biology, School of Laboratory Medicine, Bengbu Medical College, 2600 Donghai Avenue, Bengbu, Anhui, 233030, China.
Comput Struct Biotechnol J. 2021 Apr 8;19:2190-2201. doi: 10.1016/j.csbj.2021.04.006. eCollection 2021.
Colon cancer is the fourth leading cause of cancer-related death, and exhibited clinical differences among patients of different ages, including malignancy, metastasis, and mortality rate. Few studies, however, focus on the communications between aging and colon cancer. Here we identified age-dependent differentially expressed genes (DEGs) in colon cancer using TCGA transcriptome data. Through analyzing multi-omics high throughput data, including ATAC-Seq, DNaseI-Seq and ChIP-Seq, we obtained six age-dependent transcription factors in colon cancer, and their age-dependent targets, significantly affecting patients' overall survivals. Transcription factor ETS1 potentially functioned in both aging process and colon cancer progression through regulating its targets, and . In addition, comparing with its relative lower expression levels in elderly patients, higher levels of were detected in young patients, and significantly associated with larger tumor size, higher metastasis, and invasions of colon cancer, consistent with the clinical traits that young patients' colon cancer exhibited late stages with more aggressiveness. Thus, these elements may serve as keys linking aging and colon cancer, and providing new insights and basis for mechanism researches, as well as diagnosis and therapies of colon cancer, especially in young patients.
结肠癌是癌症相关死亡的第四大主要原因，并且在不同年龄的患者中表现出临床差异，包括恶性程度、转移情况和死亡率。然而，很少有研究关注衰老与结肠癌之间的关联。在这里，我们使用TCGA转录组数据鉴定了结肠癌中年龄依赖性差异表达基因（DEG）。通过分析多组学高通量数据，包括ATAC-Seq、DNaseI-Seq和ChIP-Seq，我们在结肠癌中获得了六个年龄依赖性转录因子及其年龄依赖性靶标，它们显著影响患者的总生存期。转录因子ETS1可能通过调节其靶标在衰老过程和结肠癌进展中发挥作用。此外，与老年患者中相对较低的表达水平相比，年轻患者中检测到较高水平的[此处原文缺失相关基因名称]，并且与更大的肿瘤大小、更高的转移率和结肠癌侵袭显著相关，这与年轻患者的结肠癌表现为晚期且更具侵袭性的临床特征一致。因此，这些因素可能是连接衰老与结肠癌的关键，为机制研究以及结肠癌的诊断和治疗，特别是年轻患者的诊断和治疗提供新的见解和依据。
