Veldkamp P J, Schippers E F
Leids Universitair Medisch Centrum, afd. Infectieziekten, Postbus 9600, 2300 RC Leiden.
Ned Tijdschr Geneeskd. 2002 Nov 16;146(46):2201-4.
A 48-year-old-man returned to the Netherlands from Sierra Leone and was admitted with nausea, crampy abdominal pain, myalgia, arthralgia, headache and watery diarrhoea. This was the first case of Lassa fever diagnosed in the Netherlands since 1980. Despite treatment with ribavirin, the patient died on the 16th day of illness. Prompt diagnosis of Lassa fever is critical for the timely administration of ribavirin which improves diagnosis considerably, and for the timely implementation of isolation measures. Recently, a reverse transcriptase polymerase chain reaction (RT-PCR) has become available for the rapid diagnosis of acute Lassa fever, which was implemented to diagnose this patient.
一名48岁男子从塞拉利昂返回荷兰,因恶心、腹部绞痛、肌痛、关节痛、头痛和水样腹泻入院。这是自1980年以来荷兰确诊的首例拉沙热病例。尽管使用了利巴韦林进行治疗,但患者在发病第16天死亡。拉沙热的及时诊断对于及时使用利巴韦林(这可显著改善诊断)以及及时实施隔离措施至关重要。最近,逆转录酶聚合酶链反应(RT-PCR)已可用于急性拉沙热的快速诊断,该方法被用于诊断该患者。