Kragballe Knud
Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark.
Cutis. 2002 Nov;70(5 Suppl):9-12.
Several studies have examined the combination of calcipotriene and UVB radiation in the treatment of psoriasis. Most show greater clearing with the combination than with monotherapy with either treatment. Data from one study found that calcipotriene had a UVB-sparing effect when combined with broadband UVB phototherapy, resulting in fewer UVB exposures and a lower cumulative dose. This finding suggests that patients treated with calcipotriene may be able to achieve lesion clearing with less frequent UVB radiation treatments than those not treated with calcipotriene. The combination of calcipotriene and UVB radiation does not alter the tolerability or safety of therapy. Calcipotriene may be applied at any time up to 2 hours before or immediately after UVB radiation.
多项研究探讨了卡泊三醇与紫外线B（UVB）辐射联合治疗银屑病的效果。大多数研究表明，联合治疗比单一使用任何一种疗法的疗效更佳。一项研究的数据发现，卡泊三醇与宽带UVB光疗联合使用时具有UVB节省效应，可减少UVB照射次数和累积剂量。这一发现表明，与未使用卡泊三醇治疗的患者相比，使用卡泊三醇治疗的患者可能能够通过较少次数的UVB辐射治疗实现皮损清除。卡泊三醇与UVB辐射联合使用不会改变治疗的耐受性或安全性。卡泊三醇可在UVB辐射前2小时内的任何时间或辐射后立即使用。
