Lebwohl Mark
Department of Dermatology, The Mount Sinai School of Medicine, New York, New York, USA.
Cutis. 2002 Nov;70(5 Suppl):5-8.
A sequential therapy regimen involving an initial clearing phase of daily applications of calcipotriene 0.005% ointment and halobetasol 0.05% ointment for 2 weeks, followed by halobetasol applied twice daily on weekends and calcipotriene applied twice daily on weekdays, has been shown to be effective in the management of chronic plaque psoriasis. As a clearing regimen, the combined use of halobetasol and calcipotriene for 2 weeks was superior to monotherapy with either agent. Subsequently, the use of halobetasol on weekends and calcipotriene on weekdays allowed 76% of patients to stay in remission for up to 6 months, compared with 40% of patients who applied halobetasol on weekends only and placebo on weekdays. Calcipotriene can be inactivated when mixed with some topical preparations; however, halobetasol propionate 0.05% ointment and cream have been shown to be compatible with calcipotriene for up to 2 weeks. The compatibility of calcipotriene and halobetasol permits the use of these agents together.
一种序贯治疗方案包括初始清除阶段，即每日应用0.005%的卡泊三醇软膏和0.05%的卤米松软膏2周，随后在周末每日应用两次卤米松，在工作日每日应用两次卡泊三醇，该方案已被证明对慢性斑块状银屑病的治疗有效。作为一种清除方案，卤米松和卡泊三醇联合使用2周优于单独使用任何一种药物的单一疗法。随后，在周末使用卤米松、在工作日使用卡泊三醇使76%的患者缓解长达6个月，而仅在周末使用卤米松且在工作日使用安慰剂的患者中这一比例为40%。卡泊三醇与某些局部制剂混合时可能会失活；然而，0.05%的丙酸卤倍他索软膏和乳膏已被证明与卡泊三醇可相容长达2周。卡泊三醇和卤米松的相容性使得这些药物可以一起使用。
