Hirobumi Asakura, Nakai Akihito, Power Gordon G, Tsutomu Arakia
Department of Obstetrics and Gynecology, Nippon Medical School, Tokyo, Japan.
Reprod Fertil Dev. 2002;14(5-6):355-61. doi: 10.1071/rd01021.
The purpose of the present study was to investigate the short-term effect of various body temperatures on fetal growth during uteroplacental ischaemia. Under mild hyperthermia (n = 6), normothermia (n = 6) and hypothermia (n = 6), a 30-min period of ischaemia was induced in Sprague-Dawley rat dams by clamping the uterine arteries of one uterine horn at 17 days of gestation, leaving the other horn undisturbed. Three days later, the bodyweight of the pups, and the weights of the brains, livers and placentas were compared using the Mann-Whitney U-test. Fetal bodyweight, organ and placental weights were significantly reduced in the uterine horns subjected to ischaemia under the conditions of mild hyperthermia and normothermia (P<0.05), but not with mild hypothermia, compared with the weights in undisturbed uterine horns. It was concluded that both mild hyperthermia and normothermia during ischaemia retard the growth of late-gestation rat pups, in contrast to the sparing effect of mild hypothermia.
本研究的目的是探讨不同体温对子宫胎盘缺血期间胎儿生长的短期影响。在轻度体温过高（n = 6）、正常体温（n = 6）和低温（n = 6）条件下，于妊娠第17天通过钳夹Sprague-Dawley大鼠母鼠一侧子宫角的子宫动脉诱导30分钟的缺血，另一侧子宫角不做处理。三天后，使用曼-惠特尼U检验比较幼崽的体重、脑、肝脏和胎盘的重量。与未受干扰的子宫角中的重量相比，在轻度体温过高和正常体温条件下，遭受缺血的子宫角中的胎儿体重、器官和胎盘重量显著降低（P<0.05），但在轻度低温条件下则未降低。得出的结论是，与轻度低温的保护作用相反，缺血期间的轻度体温过高和正常体温都会延缓妊娠晚期大鼠幼崽的生长。
