Bowen Martina E, Aavula Bhasker Reddy, Mash Eugene A
Department of Chemistry, The University of Arizona, Tucson 85721-0041, USA.
J Org Chem. 2002 Dec 13;67(25):9087-8. doi: 10.1021/jo0111208.
9-Methylfluorene was tested as an indicator in the titration of commonly used organometallic reagents. This indicator is readily prepared in three steps from fluorenone. In THF solution the deprotonated indicator is red and exhibits a sharp endpoint. The highly basic reagents sec-butyllithium and tert-butyllithium can be titrated in ether solution, where the color of the deprotonated indicator is yellow.
9-甲基芴被用作常用有机金属试剂滴定的指示剂进行测试。该指示剂可通过三步反应从芴酮轻松制备。在四氢呋喃（THF）溶液中，去质子化的指示剂呈红色，且终点明显。高碱性试剂仲丁基锂和叔丁基锂可在醚溶液中进行滴定，在该溶液中去质子化指示剂的颜色为黄色。
