Smaldone Gerald C
Pulmonary/Critical Care Medicine Department, State University of New York, Stony Brook, NY 11794, USA.
Respir Care. 2002 Dec;47(12):1434-41; discussion 1441-4.
Physicians are familiar with conventional nebulizers, which deliver aerosols in a relatively uncontrolled manner. As aerosol medications evolve beyond bronchodilators, the need for control of dose variability, the possibility of overdose, and the need for efficient delivery have provoked the industry to redesign aerosol delivery systems. The need to target aerosol delivery to specific lung regions has focused efforts to coordinate aerosol delivery with defined breathing maneuvers. This review summarizes the major factors affecting aerosol deposition, discusses how those factors are guiding new designs for aerosol delivery systems, and describes some examples of the improved precision and efficiency of those systems.
医生们对传统雾化器很熟悉，传统雾化器以相对不受控制的方式输送气雾剂。随着气雾剂药物从支气管扩张剂发展而来，控制剂量变异性的需求、过量用药的可能性以及高效输送的需求促使该行业重新设计气雾剂输送系统。将气雾剂输送靶向特定肺区域的需求促使人们努力将气雾剂输送与特定的呼吸动作相协调。这篇综述总结了影响气雾剂沉积的主要因素，讨论了这些因素如何指导气雾剂输送系统的新设计，并描述了这些系统在提高精度和效率方面的一些例子。
