Appendino Giovanni, Ligresti Alessia, Minassi Alberto, Daddario Nives, Bisogno Tiziana, Di Marzo Vincenzo
DiSCAFF, Viale Ferrucci 33, 28100 Novara, Italy.
Bioorg Med Chem Lett. 2003 Jan 6;13(1):43-6. doi: 10.1016/s0960-894x(02)00839-9.
Two regioisomers and 13 analogues of the putative endocannabinoid noladin ether (2-arachidonyl glyceryl ether, 2-AGE, 1) were synthesized and tested for their interaction with CB(1) receptors in rat brain membranes. The results showed that a C-20 tetra-unsaturated moiety is necessary for high affinity, and that a series of alkyl glyceryl ethers of potential occurrence in brain tissues have less affinity than 2-AGE for CB(1) receptors.
