• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

脂肪酸酰胺信号分子。

Fatty acid amide signaling molecules.

机构信息

Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.

出版信息

Bioorg Med Chem Lett. 2010 Oct 15;20(20):5959-68. doi: 10.1016/j.bmcl.2010.08.048. Epub 2010 Aug 13.

DOI:10.1016/j.bmcl.2010.08.048
PMID:20817522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2942981/
Abstract

Key studies leading to the discovery and definition of the role of endogenous fatty acid amide signaling molecules are summarized.

摘要

总结了导致内源性脂肪酸酰胺信号分子的发现和定义的关键研究。

相似文献

1
Fatty acid amide signaling molecules.脂肪酸酰胺信号分子。
Bioorg Med Chem Lett. 2010 Oct 15;20(20):5959-68. doi: 10.1016/j.bmcl.2010.08.048. Epub 2010 Aug 13.
2
Synthesis, Quantification, and Characterization of Fatty Acid Amides from In Vitro and In Vivo Sources.体外和体内来源脂肪酸酰胺的合成、定量及表征
Molecules. 2021 Apr 27;26(9):2543. doi: 10.3390/molecules26092543.
3
The enzymatic inactivation of the fatty acid amide class of signaling lipids.信号脂质中脂肪酸酰胺类的酶促失活。
Chem Phys Lipids. 2002 Dec 31;121(1-2):135-48. doi: 10.1016/s0009-3084(02)00147-0.
4
Aliphatic acid amides of the fruits of Zanthoxylum piperitum.花椒果实的脂肪酸酰胺。
Phytochemistry. 2004 Sep;65(18):2599-604. doi: 10.1016/j.phytochem.2004.08.018.
5
Microorganisms hydrolyse amide bonds; knowledge enabling read-across of biodegradability of fatty acid amides.微生物可水解酰胺键；该知识有助于推断脂肪酸酰胺的生物降解性。
Biodegradation. 2014 Jul;25(4):605-14. doi: 10.1007/s10532-014-9685-2. Epub 2014 Feb 9.
6
Melonoside A: An ω-Glycosylated Fatty Acid Amide from the Far Eastern Marine Sponge Melonanchora kobjakovae.瓜诺索林 A：来自远东海域海绵瓜诺索拉科巴科夫的 ω-糖基化脂肪酸酰胺。
Org Lett. 2016 Jul 15;18(14):3478-81. doi: 10.1021/acs.orglett.6b01678. Epub 2016 Jun 30.
7
Bioactive amides of fatty acids.脂肪酸的生物活性酰胺
Biochemistry (Mosc). 1998 Jan;63(1):22-30.
8
Targeted lipidomics: fatty acid amides and pain modulation.靶向脂质组学：脂肪酸酰胺与疼痛调节
Prostaglandins Other Lipid Mediat. 2005 Sep;77(1-4):35-45. doi: 10.1016/j.prostaglandins.2004.09.017. Epub 2004 Nov 24.
9
Functional disassociation of the central and peripheral fatty acid amide signaling systems.中枢和外周脂肪酸酰胺信号系统的功能解离
Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10821-6. doi: 10.1073/pnas.0401292101. Epub 2004 Jul 9.
10
Columbamides D and E: Chlorinated Fatty Acid Amides from the Marine Cyanobacterium Moorea bouillonii Collected in Malaysia.海兔酰胺 D 和 E：从马来西亚采集的海洋蓝细菌 Moorea bouillonii 中分离出的氯代脂肪酸酰胺。
Org Lett. 2017 Aug 18;19(16):4231-4234. doi: 10.1021/acs.orglett.7b01869. Epub 2017 Aug 7.

引用本文的文献

1
Metabolic Effects of Cellular Necrosis Caused by Exfoliative Toxin C (ExhC) from .由……的剥脱毒素C（ExhC）引起的细胞坏死的代谢效应 。 你提供的原文似乎不完整，“from”后面缺少具体内容。
J Proteome Res. 2025 Jul 4;24(7):3261-3271. doi: 10.1021/acs.jproteome.4c01029. Epub 2025 May 22.
2
Aminolipids in bacterial membranes and the natural environment.细菌膜和自然环境中的氨基脂质。
ISME J. 2024 Jan 8;18(1). doi: 10.1093/ismejo/wrae229.
3
Fatty Acid Amides Suppress Proliferation via Cannabinoid Receptors and Promote the Apoptosis of C6 Glioma Cells in Association with Akt Signaling Pathway Inhibition.脂肪酸酰胺通过大麻素受体抑制增殖，并与Akt信号通路抑制相关，促进C6胶质瘤细胞凋亡。
Pharmaceuticals (Basel). 2024 Jul 2;17(7):873. doi: 10.3390/ph17070873.
4
Dynamics of the lipid body lipidome in the oleaginous yeast Yarrowia sp.油脂体脂类组学在产油酵母 Yarrowia sp. 中的动态变化
FEMS Yeast Res. 2024 Jan 9;24. doi: 10.1093/femsyr/foae021.
5
Endocannabinoid levels in female-sexed individuals with diagnosed depression: a systematic review.诊断为抑郁症的女性个体中的内源性大麻素水平：系统评价。
BMC Womens Health. 2024 Jun 17;24(1):350. doi: 10.1186/s12905-024-03168-y.
6
The association of circulating endocannabinoids with neuroimaging and blood biomarkers of neuro-injury.循环内源性大麻素与神经损伤的神经影像学和血液生物标志物的关联。
Alzheimers Res Ther. 2023 Sep 12;15(1):154. doi: 10.1186/s13195-023-01301-x.
7
Anti-Inflammatory Activity of Black Soldier Fly Oil Associated with Modulation of TLR Signaling: A Metabolomic Approach.黑水虻油的抗炎活性与 TLR 信号调节有关：一种代谢组学方法。
Int J Mol Sci. 2023 Jun 25;24(13):10634. doi: 10.3390/ijms241310634.
8
Nontargeted metabolomics analysis of follicular fluid in patients with endometriosis provides a new direction for the study of oocyte quality.子宫内膜异位症患者卵泡液的非靶向代谢组学分析为卵母细胞质量的研究提供了新方向。
MedComm (2020). 2023 May 30;4(3):e302. doi: 10.1002/mco2.302. eCollection 2023 Jun.
9
Untargeted Metabolomics to Characterize the Urinary Chemical Landscape of E-Cigarette Users.非靶向代谢组学分析电子烟使用者尿液中的化学物质特征。
Chem Res Toxicol. 2023 Apr 17;36(4):630-642. doi: 10.1021/acs.chemrestox.2c00346. Epub 2023 Mar 13.
10
Metabolic Mechanism of sp. LM24 under Abamectin Stress. sp. LM24 在阿维菌素胁迫下的代谢机制。
Int J Environ Res Public Health. 2023 Feb 9;20(4):3068. doi: 10.3390/ijerph20043068.

本文引用的文献

1
N-arachidonoyl glycine, an abundant endogenous lipid, potently drives directed cellular migration through GPR18, the putative abnormal cannabidiol receptor.N-花生四烯酰甘氨酸是一种丰富的内源性脂质，通过假定的异常大麻素受体 GPR18 强烈驱动定向细胞迁移。
BMC Neurosci. 2010 Mar 26;11:44. doi: 10.1186/1471-2202-11-44.
2
X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase.X 射线晶体学分析结合脂肪酸酰胺水解酶人源化变体的 alpha-酮杂环抑制剂。
J Med Chem. 2010 Jan 14;53(1):230-40. doi: 10.1021/jm9012196.
3
Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures.从共晶体结构揭示α-酮杂环抑制剂对人源化脂肪酸酰胺水解酶的结合及失活机制
J Am Chem Soc. 2009 Aug 5;131(30):10497-506. doi: 10.1021/ja902694n.
4
Novel endogenous N-acyl glycines identification and characterization.新型内源性N-酰基甘氨酸的鉴定与表征。
Vitam Horm. 2009;81:191-205. doi: 10.1016/S0083-6729(09)81008-X.
5
Is GPR55 an anandamide receptor?GPR55是一种花生四烯乙醇胺受体吗？
Vitam Horm. 2009;81:111-37. doi: 10.1016/S0083-6729(09)81005-4.
6
The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways.内源性大麻素花生四烯乙醇胺通过两条不同途径作为信号脂质N-花生四烯酰甘氨酸的前体。
BMC Biochem. 2009 May 21;10:14. doi: 10.1186/1471-2091-10-14.
7
N-acylethanolamines, anandamide and food intake.N-酰基乙醇胺、花生四烯酸乙醇胺与食物摄入。
Biochem Pharmacol. 2009 Sep 15;78(6):553-60. doi: 10.1016/j.bcp.2009.04.024. Epub 2009 May 4.
8
Enhancement of the hypotensive effects of intrathecally injected endocannabinoids by the entourage compound palmitoylethanolamide.随行化合物棕榈酰乙醇胺增强鞘内注射内源性大麻素的降压作用。
Eur J Pharmacol. 2009 May 21;610(1-3):75-80. doi: 10.1016/j.ejphar.2009.03.021. Epub 2009 Mar 14.
9
Anti-inflammatory effect of palmitoylethanolamide on human adipocytes.棕榈酰乙醇胺对人脂肪细胞的抗炎作用。
Obesity (Silver Spring). 2009 Mar;17(3):431-8. doi: 10.1038/oby.2008.591. Epub 2009 Jan 8.
10
Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors.脂肪酸酰胺水解酶（FAAH）抑制剂的发现与开发。
J Med Chem. 2008 Dec 11;51(23):7327-43. doi: 10.1021/jm800311k.