Küpeli Esra, Koşar Müberra, Yeşilada Erdem, Hüsnü K, Başer C
Gazi University, Faculty of Pharmacy, Etiler 06330, Ankara, Turkey.
Life Sci. 2002 Dec 27;72(6):645-57. doi: 10.1016/s0024-3205(02)02200-2.
Roots and barks of various Berberis species are used as folk remedy for the treatment of various inflammatory diseases such as lumbago, rheumatism and to reduce fever. Six isoquinoline alkaloids namely berberine, berbamine, palmatine, oxyacanthine, magnoflorine, and columbamine were isolated as the main components of alkaloidal fraction from the roots of Turkish Berberis species and effects were studied using various in vivo models in mice. All alkaloids inhibited inflammations in varying degrees, among them berberine, berbamine and palmatine were shown to possess significant and dose-dependent inhibitory activity against serotonin-induced hind paw oedema both on oral and topical applications and acetic acid-induced increase in vascular permeability on oral administration. Moreover, these three alkaloids were also shown to possess dose-dependent antinociceptive activity, which assessed by using the model based on the inhibition of p-benzoquinone-induced writhing movements as well as antipyretic activity on FCA-induced increased rectal temperature on subacute administration. However, all alkaloids induced gastric lesions in varying degrees.
多种小檗属植物的根和树皮被用作民间药物，用于治疗各种炎症性疾病，如腰痛、风湿病以及退烧。从小檗属土耳其物种的根中分离出六种异喹啉生物碱，即小檗碱、小檗胺、巴马汀、尖刺碱、木兰碱和哥伦比亚胺，作为生物碱部分的主要成分，并在小鼠的各种体内模型中研究了它们的作用。所有生物碱都不同程度地抑制炎症，其中小檗碱、小檗胺和巴马汀在口服和局部应用时均显示出对血清素诱导的后爪水肿以及口服给药时乙酸诱导的血管通透性增加具有显著的剂量依赖性抑制活性。此外，这三种生物碱还显示出剂量依赖性的抗伤害感受活性，这是通过基于对对苯醌诱导的扭体运动的抑制以及亚急性给药时对弗氏完全佐剂诱导的直肠温度升高的解热活性的模型来评估的。然而，所有生物碱都不同程度地引起胃部损伤。
