Brown Alan S
Midwest Heart Specialists Disease Prevention Center, Naperville, Illinois 60540, USA.
Am J Cardiol. 2002 Nov 20;90(10B):44K-49K. doi: 10.1016/s0002-9149(02)02969-7.
Combination drug therapy has been used in the management of dyslipidemia by lipid clinics since the early 1980s. The explosion of statin use in the early and mid-1990s has caused a shift to monotherapy for dyslipidemia. However, the use of combination therapy has reemerged as a treatment option for patients who have elevated triglyceride and low-density lipoprotein (LDL) cholesterol levels as more attention is now focused on non-high-density lipoprotein cholesterol. This article discusses the use of combination therapy in a lipid clinic based on experiences from a multisite clinical practice of >48 physicians and 80,000 patients. Approaches to LDL lowering for complex dyslipidemias and management strategies for specific lipid-lowering therapies are provided.
自20世纪80年代初以来，脂质诊所一直采用联合药物疗法来管理血脂异常。20世纪90年代初和中期他汀类药物的大量使用导致血脂异常的治疗转向单一疗法。然而，随着现在更多的注意力集中在非高密度脂蛋白胆固醇上，联合疗法作为甘油三酯和低密度脂蛋白（LDL）胆固醇水平升高患者的一种治疗选择再次出现。本文基于48位以上医生和80000名患者的多中心临床实践经验，讨论脂质诊所中联合疗法的使用。提供了针对复杂血脂异常降低LDL的方法以及特定降脂疗法的管理策略。
