Ferguson Sarah E, Smith Graeme N, Salenieks Mary Ellen, Windrim Rory, Walker Mark C
University of Toronto, Women's College Hospital, and Mount Sinai Hospital, Ontario, Canada.
Obstet Gynecol. 2002 Dec;100(6):1250-6. doi: 10.1016/s0029-7844(02)02380-3.
To estimate if there were dietary or socioeconomic factors associated with preterm premature rupture of membranes (PROM).
In this case-control study, women with preterm PROM (n = 46) were compared with healthy pregnant women matched for gestational age and vitamin supplementation. Measurements included fasting homocysteine, red blood cell folate, albumin, creatinine, and complete blood count. Dietary intake was determined by a food frequency questionnaire. Socioeconomic and demographic factors were recorded.
There were no differences between fasting homocysteine, red blood cell folate, and vitamin B(12) levels and dietary intake between patients and controls. There was lower hemoglobin in women with preterm PROM compared with the controls (P <.001). There was a three-fold increased odds of having a total family income of less than $25,000 (Canadian) (odds ratio 3.1, 95% confidence interval 1.6, 6) in women with preterm PROM.
Preterm PROM is associated with low maternal hemoglobin and low socioeconomic status. There was no association with nutritional intake. The lower hemoglobin level may be a marker for subclinical infection.
评估是否存在与早产胎膜早破（PROM）相关的饮食或社会经济因素。
在这项病例对照研究中，将早产胎膜早破的女性（n = 46）与孕周和维生素补充情况相匹配的健康孕妇进行比较。测量指标包括空腹同型半胱氨酸、红细胞叶酸、白蛋白、肌酐和全血细胞计数。通过食物频率问卷确定饮食摄入量。记录社会经济和人口统计学因素。
患者与对照组之间的空腹同型半胱氨酸、红细胞叶酸和维生素B12水平以及饮食摄入量无差异。早产胎膜早破女性的血红蛋白水平低于对照组（P <.001）。早产胎膜早破女性家庭总收入低于25,000加元的几率增加了两倍（比值比3.1，95%置信区间1.6, 6）。
早产胎膜早破与孕妇血红蛋白水平低和社会经济地位低有关。与营养摄入无关。较低的血红蛋白水平可能是亚临床感染的一个指标。
