Crosby Heather A, Nijjar Sarbjit S, de Goyet Jean de Ville, Kelly Deirdre A, Strain Alastair J
School of Biosciences, Birmingham, UK.
Semin Cell Dev Biol. 2002 Dec;13(6):397-403. doi: 10.1016/s108495210200126x.
Stem-like cells have been identified in liver that are able to differentiate in vivo and in culture to biliary epithelial cells (BEC), hepatocytes and oval cells. The growth factors/cytokines and signal pathways required for the differentiation processes are beginning to be evaluated. There is increasing evidence to suggest that these stem-like cells may originate from both the bone marrow population or from a precursor remnant from liver embryogenesis, as they share many of the same markers (CD34, c-kit, CD45). Most recently, it has been shown that a population of progenitor cells can copurify with mesenchymal bone marrow cells and differentiate under specific culture conditions to form both hepatic epithelial and also endothelial cells. The interaction of haemopoietic and mesenchymal stem cells needs further evaluation. The close association of ductular reactive cells and neovessels in end-stage cholestatic liver diseases and the relation to Jagged/Notch signalling pathway may be important in the regulation of stem cells to form both biliary epithelial and endothelial cells.
已在肝脏中鉴定出干细胞样细胞，它们能够在体内和培养条件下分化为胆管上皮细胞（BEC）、肝细胞和卵圆细胞。分化过程所需的生长因子/细胞因子和信号通路正开始得到评估。越来越多的证据表明，这些干细胞样细胞可能起源于骨髓群体或肝脏胚胎发育过程中残留的前体细胞，因为它们具有许多相同的标志物（CD34、c-kit、CD45）。最近的研究表明，一群祖细胞可与间充质骨髓细胞共同纯化，并在特定培养条件下分化形成肝上皮细胞和内皮细胞。造血干细胞和间充质干细胞之间的相互作用需要进一步评估。终末期胆汁淤积性肝病中导管反应性细胞与新生血管的密切关联以及与Jagged/Notch信号通路的关系，可能在调节干细胞形成胆管上皮细胞和内皮细胞方面具有重要意义。
