Smriga Miro, Kameishi Makiko, Uneyama Hisayuki, Torii Kunio
Ajinomoto Company Incorporated, Institute of Life Sciences, 210-8681 Kawasaki, Japan.
J Nutr. 2002 Dec;132(12):3744-6. doi: 10.1093/jn/132.12.3744.
Little is known about the psychobehavioral consequences of a dietary deficiency of the amino acid, L-lysine. This report demonstrates that a 4-d long L-lysine deficiency in rats interfered with the normal circadian release of the neurotransmitter serotonin, but not dopamine, measured by in vivo microdialysis in the central nucleus of the amygdala. L-Lysine deficiency was induced by feeding rats a L-lysine-deficient diet. Controls were pair-fed a L-lysine-sufficient diet. Footshock stress-induced anxiety, measured in an elevated plus-maze paradigm, and wrap-restraint stress-stimulated fecal excretion were significantly greater in the L-lysine-deficient rats than in the controls. We conclude that a severe deficiency of dietary L-lysine enhances serotonin release in the amygdala, with subsequent changes in psychobehavioral responses to stress.
关于膳食中缺乏氨基酸L-赖氨酸的心理行为后果，目前所知甚少。本报告表明，给大鼠喂食4天的L-赖氨酸缺乏饮食会干扰神经递质血清素的正常昼夜节律释放，但不会干扰多巴胺的释放，这是通过杏仁核中央核的体内微透析测量得出的。通过给大鼠喂食L-赖氨酸缺乏饮食来诱导L-赖氨酸缺乏。对照组则配对喂食L-赖氨酸充足的饮食。在高架十字迷宫实验中测量的足底电击应激诱导的焦虑，以及束缚应激刺激的粪便排泄，在L-赖氨酸缺乏的大鼠中显著高于对照组。我们得出结论，膳食中严重缺乏L-赖氨酸会增强杏仁核中血清素的释放，随后会改变对应激的心理行为反应。
