The First School of Clinical Medicine, Southern Medical University, Guangdong, 510515, China.
Shenzhen Hospital, Southern Medical University, Shenzhen Clinical Medical College, Southern Medical University, Guangdong, 518101, China.
Amino Acids. 2023 Nov;55(11):1487-1499. doi: 10.1007/s00726-023-03334-w. Epub 2023 Oct 9.
Apart from cancer, metabolic reprogramming is also prevalent in other diseases, such as bacterial infections. Bacterial infections can affect a variety of cells, tissues, organs, and bodies, leading to a series of clinical diseases. Common Pathogenic bacteria include Helicobacter pylori, Salmonella enterica, Mycobacterium tuberculosis, Staphylococcus aureus, and so on. Amino acids are important and essential nutrients in bacterial physiology and support not only their proliferation but also their evasion of host immune defenses. Many pathogenic bacteria or opportunistic pathogens infect the host and lead to significant changes in metabolites, especially the proteinogenic amino acids, to inhibit the host's immune mechanism to achieve its immune evasion and pathogenicity. Here, we review the regulation of host metabolism, while host cells are infected by some common pathogenic bacteria, and discuss how amino acids of metabolic reprogramming affect bacterial infections, revealing the potential adjunctive application of amino acids alongside antibiotics.
除了癌症，代谢重编程在其他疾病中也很普遍，如细菌感染。细菌感染会影响多种细胞、组织、器官和机体，导致一系列临床疾病。常见的病原菌包括幽门螺杆菌、肠炎沙门氏菌、结核分枝杆菌、金黄色葡萄球菌等。氨基酸是细菌生理中重要且必需的营养物质，不仅支持其增殖，还支持其逃避宿主免疫防御。许多病原菌或机会性病原体感染宿主，导致代谢物发生显著变化，特别是蛋白质氨基酸，以抑制宿主的免疫机制，从而实现其免疫逃逸和致病性。在这里，我们综述了宿主代谢的调控，当宿主细胞受到一些常见病原菌感染时，讨论了代谢重编程中的氨基酸如何影响细菌感染，揭示了氨基酸与抗生素联合应用的潜在辅助作用。
