肝硬化患者食管静脉曲张套扎术后早期食管下括约肌压力升高：一个有趣的现象。
Early increase of lower oesophageal sphincter pressure after band ligation of oesophageal varices in cirrhotics: an intriguing phenomenon.
作者信息
Avgerinos Alec, Viazis Nikos, Armonis Anastasios, Vlachogiannakos Jiannis, Rekoumis George, Stefanidis Gerasimos, Papadimitriou Nikos, Manolakopoulos Spilios, Raptis Sotiris A
机构信息
2nd Department of Gastroenterology, Propaedeutic, Athens University, Evangelismos Hospital, Greece.
出版信息
Eur J Gastroenterol Hepatol. 2002 Dec;14(12):1319-23. doi: 10.1097/00042737-200212000-00006.
AIM
We conducted a prospective, randomized comparison of endoscopic variceal ligation, sclerotherapy and metoclopramide injection in order to evaluate their early effect on lower oesophageal sphincter pressure.
METHODS
Twenty-six patients with established cirrhosis and an episode of variceal bleeding controlled by one session of endoscopic therapy were randomized to undergo an oesophageal manometry. The patients' lower oesophageal sphincter pressure was evaluated, prior to and immediately after a single session of ligation (n = 10), a single session of sclerotherapy (n = 8) or a bolus injection of 20 mg metoclopramide hydrochloride (n = 8).
RESULTS
Ligation produced a higher early increase in lower oesophageal sphincter pressure (from 12.3 +/- 2.3 to 27.8 +/- 3.0 mmHg) as compared with sclerotherapy (from 13.6 +/- 2.5 to 22.4 +/- 4.5 mmHg) or metoclopramide injection (from 14.6 +/- 3.2 to 22.5 +/- 2.9 mmHg); (P = 0.0001).
CONCLUSION
Our data indicate that ligation of oesophageal varices produces an early increase in lower oesophageal sphincter pressure in cirrhotic patients.
目的
我们进行了一项前瞻性随机对照研究，比较内镜下静脉曲张结扎术、硬化疗法和甲氧氯普胺注射，以评估它们对食管下括约肌压力的早期影响。
方法
26例确诊为肝硬化且经一次内镜治疗控制住静脉曲张出血的患者被随机分组进行食管测压。在单次结扎（n = 10）、单次硬化疗法（n = 8）或推注20 mg盐酸甲氧氯普胺（n = 8）之前及之后，对患者的食管下括约肌压力进行评估。
结果
与硬化疗法（从13.6±2.5 mmHg升至22.4±4.5 mmHg）或甲氧氯普胺注射（从14.6±3.2 mmHg升至22.5±2.9 mmHg）相比，结扎术使食管下括约肌压力早期升高幅度更大（从12.3±2.3 mmHg升至27.8±3.0 mmHg）；（P = 0.0001）。
结论
我们的数据表明，食管静脉曲张结扎术可使肝硬化患者食管下括约肌压力早期升高。
Zotero 插件