Uchio Yuji, Ochi Mitsuo, Ryoke Koji, Sakai Yasuo, Ito Youhei, Kuwata Suguru
Department of Orthopaedics, Shimane Medical University, Izumo, Japan.
J Shoulder Elbow Surg. 2002 Nov-Dec;11(6):570-5. doi: 10.1067/mse.2002.126769.
To reveal whether neuropeptides and cytokines affect the pathogenesis of tennis elbow, expressions of substance P, calcitonin gene-related peptide, interleukin 1 alpha, and transforming growth factor beta1 at the origin of the extensor carpi radialis brevis muscle were investigated in patients with tennis elbow (n = 10). Innervation in the origin was determined with use of the protein gene product 9.5. Substance P-like immunoreactivity and calcitonin gene-related peptide-like immunoreactivity were observed in the nerve fibers around small vessels without apparent infiltration of inflammatory cells. Cells showing positive interleukin 1 alpha or transforming growth factor beta1 immunoreactivity were noted in small vessels and the dense collagen meshwork in 5 of 10 cases. The results suggested that these neuropeptides and cytokines might promote inflammation and stimulate proliferation and matrix synthesis of fibroblasts, contributing to the pathology of tennis elbow.
为了揭示神经肽和细胞因子是否影响网球肘的发病机制，我们对10例网球肘患者桡侧腕短伸肌起点处P物质、降钙素基因相关肽、白细胞介素1α和转化生长因子β1的表达进行了研究。使用蛋白基因产物9.5确定起点处的神经支配情况。在小血管周围的神经纤维中观察到P物质样免疫反应性和降钙素基因相关肽样免疫反应性，未见明显炎症细胞浸润。在10例患者中的5例中，在小血管和致密胶原网中发现了白细胞介素1α或转化生长因子β1免疫反应阳性的细胞。结果表明，这些神经肽和细胞因子可能促进炎症反应，刺激成纤维细胞增殖和基质合成，从而导致网球肘的病理改变。
