白细胞介素-28、白细胞介素-29及其Ⅱ类细胞因子受体白细胞介素-28受体

IL-28, IL-29 and their class II cytokine receptor IL-28R.

作者信息

Sheppard Paul, Kindsvogel Wayne, Xu Wenfeng, Henderson Katherine, Schlutsmeyer Stacy, Whitmore Theodore E, Kuestner Rolf, Garrigues Ursula, Birks Carl, Roraback Jenny, Ostrander Craig, Dong Dennis, Shin Jinu, Presnell Scott, Fox Brian, Haldeman Betty, Cooper Emily, Taft David, Gilbert Teresa, Grant Francis J, Tackett Monica, Krivan William, McKnight Gary, Clegg Chris, Foster Don, Klucher Kevin M

机构信息

ZymoGenetics, Inc., 1201 Eastlake Avenue E., Seattle, WA 98102, USA.

出版信息

Nat Immunol. 2003 Jan;4(1):63-8. doi: 10.1038/ni873. Epub 2002 Dec 2.

DOI:10.1038/ni873

PMID:12469119

Abstract

Cytokines play a critical role in modulating the innate and adaptive immune systems. Here, we have identified from the human genomic sequence a family of three cytokines, designated interleukin 28A (IL-28A), IL-28B and IL-29, that are distantly related to type I interferons (IFNs) and the IL-10 family. We found that like type I IFNs, IL-28 and IL-29 were induced by viral infection and showed antiviral activity. However, IL-28 and IL-29 interacted with a heterodimeric class II cytokine receptor that consisted of IL-10 receptor beta (IL-10Rbeta) and an orphan class II receptor chain, designated IL-28Ralpha. This newly described cytokine family may serve as an alternative to type I IFNs in providing immunity to viral infection.

摘要

细胞因子在调节先天性和适应性免疫系统中发挥着关键作用。在此，我们从人类基因组序列中鉴定出一个由三种细胞因子组成的家族，分别命名为白细胞介素28A（IL-28A）、IL-28B和IL-29，它们与I型干扰素（IFN）和IL-10家族有较远的亲缘关系。我们发现，与I型IFN一样，IL-28和IL-29可由病毒感染诱导产生，并具有抗病毒活性。然而，IL-28和IL-29与一种异二聚体II类细胞因子受体相互作用，该受体由IL-10受体β（IL-10Rβ）和一个孤儿II类受体链（命名为IL-28Rα）组成。这个新描述的细胞因子家族可能在提供抗病毒感染免疫力方面作为I型IFN的替代物。