Instituto de Física de São Carlos, Universidade de São Paulo, Avenida Trabalhador São Carlense 400, São Carlos, SP, CEP 13566-590, Brazil.
Cell Mol Life Sci. 2010 Sep;67(17):2909-35. doi: 10.1007/s00018-010-0380-0. Epub 2010 May 8.
The IL-10 family of cytokines is comprised of IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and IFN-lambdas (IL-28A, IL-28B, and IL-29). The IL-10 family members bind to shared class II cytokine receptor chains that associate in various combinations in heterodimeric complexes. Upon interleukin/receptor complex formation, these proteins switch on the Jak/STAT pathway and elicit pleiotropic biological responses whose variety sharply contrasts with their structural similarities. IL-10 family members are involved in several human diseases and health conditions and hence their structural analyses may provide valuable information to design specific therapeutic strategies. In this review, we describe the human interleukin-10 family of cytokines, focusing on their structures and functions, with particular attention given to IL-22 and IL-10. We report on the recently published structures of IL-10 cytokine family members and their complexes with cognate transmembrane and soluble receptors as well as on interleukin physiology and physiopathology.
白细胞介素-10 家族细胞因子包括白细胞介素-10、白细胞介素-19、白细胞介素-20、白细胞介素-22、白细胞介素-24、白细胞介素-26 和 IFN-λs（白细胞介素-28A、白细胞介素-28B 和白细胞介素-29）。白细胞介素-10 家族成员结合到共享的 II 类细胞因子受体链上，这些受体链以各种组合形成异二聚体复合物。在白细胞介素/受体复合物形成后，这些蛋白激活 Jak/STAT 途径，并引发多种生物学反应，其多样性与它们的结构相似性形成鲜明对比。白细胞介素-10 家族成员参与多种人类疾病和健康状况，因此对其结构的分析可能为设计特定的治疗策略提供有价值的信息。在这篇综述中，我们描述了人类白细胞介素-10 家族细胞因子，重点介绍了它们的结构和功能，特别关注白细胞介素-22 和白细胞介素-10。我们报告了白细胞介素-10 家族细胞因子及其与同源跨膜和可溶性受体的复合物的最新发表结构，以及白细胞介素的生理学和病理生理学。
