Hillis Argye E, Wityk Robert J, Barker Peter B, Caramazza Alfonso
Department of Neurology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Baltimore, Maryland 21287, USA.
Nat Neurosci. 2003 Jan;6(1):19-20. doi: 10.1038/nn982.
Functional imaging data collected during cognitive tasks show which brain regions are active during those tasks, but do not necessarily indicate which regions are essential for those tasks. Here, in a study of two cases of selectively impaired written naming of verbs after focal brain ischemia, we combined imaging and behavioral testing to unambiguously identify brain regions that are crucial for a specific cognitive process. We used magnetic resonance perfusion imaging to show that the selective impairment in each case was due to hypoperfusion (low blood flow) in left posterior inferior frontal gyrus (PIFG) and precentral gyrus (PrG); the impairment was immediately reversed when blood flow was restored to these regions, indicating that parts of the left frontal lobe are crucial for representing and processing verbs.
在认知任务中收集的功能成像数据显示了哪些脑区在这些任务期间处于活跃状态，但不一定表明哪些区域对这些任务至关重要。在此，在一项针对两例局灶性脑缺血后动词书写命名选择性受损病例的研究中，我们将成像与行为测试相结合，以明确识别对特定认知过程至关重要的脑区。我们使用磁共振灌注成像显示，每例中的选择性损伤是由于左后下额叶回（PIFG）和中央前回（PrG）灌注不足（低血流量）所致；当这些区域的血流恢复时，损伤立即得到逆转，这表明左额叶的部分区域对于表征和处理动词至关重要。
