Lee Dae Ho, Kim Inho, Song Hun Ho, Jung Joo Young, Kim Dae Young, Lee Keun Wook, Kim Tae-You, Heo Dae Seog, Bang Yung-Jue, Ha Sung Whan, Park Jae-Gahb, Kim Noe Kyeong
Department of Internal Medicine, Seoul National University College of Medicine, Korea.
Oncol Rep. 2003 Jan-Feb;10(1):101-4.
This study was conducted to investigate the efficacy of the induction chemotherapy followed by radiotherapy in anal cancer. Twenty-three patients diagnosed with anal cancer between March 1991 and February 1999 were treated with induction chemotherapy with 5-fluorouracil based regimens followed by external beam radiation. After a median follow-up of 78 months, the overall survival and the disease-free survival at 5 years was 71.3 and 67.5%, respectively. The colostomy-free survival at 5 years was 91%, as the inguinal lymph nodes were the most frequent site of relapse. Serious side effects did not occur and late complications did not develop either. Induction chemotherapy followed by radiotherapy in patients with anal cancer is effective in terms of its response and preserving the anal sphincter without serious acute and late complications.
本研究旨在探讨诱导化疗后放疗在肛管癌治疗中的疗效。1991年3月至1999年2月期间诊断为肛管癌的23例患者接受了以5-氟尿嘧啶为基础方案的诱导化疗，随后接受外照射放疗。中位随访78个月后，5年总生存率和无病生存率分别为71.3%和67.5%。5年无结肠造口生存率为91%，因为腹股沟淋巴结是最常见的复发部位。未出现严重副作用，也未发生晚期并发症。肛管癌患者诱导化疗后放疗在反应和保留肛门括约肌方面有效，且无严重的急性和晚期并发症。
