Stein P D, Sabbah H N
Am Heart J. 1976 Feb;91(2):219-27. doi: 10.1016/s0002-8703(76)80577-7.
An expression representative of the rate of change of ventricular power during ejection was derived. The primary advantages of the expression are its theoretical value and its ability to characterize ventricular performance. The rate of change of ventricular power, measured during ejection, is virtually free of assumptions. It has a fluid dynamic as well as a physiological meaning. It serves in an integrative fashion by combining terms previously shown to be of functional significance. Studies in dogs show that it reflects alterations of the inotropic state yet is relatively independent of alterations of preload or afterload. In nine dogs isoproterenol caused the peak rate of change of power to increase from (10 +/- 2) X 10(8) to (15 +/- 3) X 10(8) dynes-cm. sec.-2 (mean +/- S.E.) (P less than 0.01). Propranolol produced a reduction from (10 +/- 2) X 108 to (6 +/- 1) X 10(8) dynes-cm. sec.-2 (P less than 0.001). An increased afterload induced by angiotensin caused no change of the peak rate of change of power. Augmentation of the preload with dextran, which caused a 40 per cent increase of the end-diastolic volume, produced a statistically insignificant increase of the peak rate of change of power from (12 +/- 3) X 10(8) TO (16 +/- 4) X 10(8) dynes-cm. sec.-2 The rate of change of ventricular power, measured during ejection, therefore appears to be a useful and meaningful indicator of ventricular performance that has many desirable characteristics.
推导出了一个代表射血期间心室功率变化率的表达式。该表达式的主要优点在于其理论价值及其表征心室功能的能力。在射血期间测量的心室功率变化率几乎不受假设的影响。它具有流体动力学以及生理学意义。它通过组合先前显示具有功能意义的项以综合的方式发挥作用。对狗的研究表明，它反映了心肌收缩状态的改变，但相对独立于前负荷或后负荷的改变。在9只狗中，异丙肾上腺素使功率变化的峰值速率从(10±2)×10⁸增加到(15±3)×10⁸达因 - 厘米·秒⁻²（平均值±标准误）（P<0.01）。普萘洛尔使其从(10±2)×10⁸降低到(6±1)×10⁸达因 - 厘米·秒⁻²（P<0.001）。血管紧张素引起的后负荷增加并未导致功率变化峰值速率的改变。用右旋糖酐增加前负荷，这使舒张末期容积增加了40%，导致功率变化峰值速率从(12±3)×10⁸增加到(16±4)×10⁸达因 - 厘米·秒⁻²，但在统计学上无显著差异。因此，在射血期间测量的心室功率变化率似乎是心室功能的一个有用且有意义的指标，具有许多理想的特性。
