Hagemann K, Meyer J, von Essen R, Krebs W, Effert S
Br Heart J. 1979 Feb;41(2):231-7. doi: 10.1136/hrt.41.2.231.
Peak and mean left ventricular ejection power were measured during atrial pacing in 6 normal subjects (group I), 6 patients with coronary artery disease without myocardial infarction (group IIa), and 10 patients with coronary artery disease after myocardial infarction (group IIb). Pacing rates were 80 and 120/min. Power was determined by computer analysis of pressure, volume, and time. Data were normalised by end-diastolic volume and left ventricular muscle mass. Peak left ventricular ejection power normalised by end-diastolic volume values at a pacing rate of 120 min were significantly lower in group IIa and IIb than in normal subjects. Mean muscle mass in normal subjects was 179 g and in group IIa 216 g (P smaller than 0.05). Peak power normalised by muscle mass in normal subjects tended to increase at 120/min whereas in group IIa it declined by 26 per cent (P less than 0.001). These data indicate that the energy output of the left ventricle at rest may be the same in patients with significant coronary artery disease as in normal subjects. Increasing the heart rate from 80 to 120/min in a normal myocardium augments power but in coronary artery disease it remains static or falls.
在6名正常受试者（I组）、6名无心肌梗死的冠心病患者（IIa组）和10名心肌梗死后冠心病患者（IIb组）进行心房起搏期间，测量左心室射血峰值功率和平均功率。起搏频率为80次/分钟和120次/分钟。功率通过对压力、容积和时间进行计算机分析来确定。数据以舒张末期容积和左心室肌肉质量进行标准化。在起搏频率为120次/分钟时，IIa组和IIb组经舒张末期容积值标准化后的左心室射血峰值功率显著低于正常受试者。正常受试者的平均肌肉质量为179克，IIa组为216克（P小于0.05）。正常受试者经肌肉质量标准化后的峰值功率在120次/分钟时趋于增加，而IIa组则下降了26%（P小于0.001）。这些数据表明，严重冠心病患者静息时左心室的能量输出可能与正常受试者相同。正常心肌将心率从80次/分钟提高到120次/分钟时功率增加，但在冠心病患者中功率保持不变或下降。
