Plancoulaine Sabine, Abel Laurent, Gessain Antoine
INSERM U550, Laboratoire de Génétique Humaine des Maladies Infectieuses, Faculté de Médecine Necker-Enfants Malades, 156, rue de Vaugirard, 75015 Paris, France.
Pathol Biol (Paris). 2002 Oct;50(8):496-502. doi: 10.1016/s0369-8114(02)00317-6.
Human herpesvirus 8 (HHV-8), also called Kaposi's sarcoma-associated herpesvirus (KSHV), is not a ubiquitous virus. In countries with a low viral seroprevalence (< 5% in adult general population) as the USA, Northern Europe and Asia, the infection concerns essentially homosexual men. In this latter population, the viral transmission seems to occur during sex. In endemic countries (HHV-8 seroprevalence between 10-70% in the adult general population) as in the Mediterranean basin (Italy, Greece), and Africa (East and Central Africa), men, women and children are infected. In these countries, HHV-8 seroprevalence increases with age and often reaches adult rates before the end of puberty. Viral transmission, in general endemic populations, seems to occur from mother to child and between sibs whereas heterosexual transmission appears to concern essentially groups at risk for sexual transmitted diseases. Saliva is a major reservoir of HHV-8.
人类疱疹病毒8型（HHV-8），也称为卡波西肉瘤相关疱疹病毒（KSHV），并非一种普遍存在的病毒。在病毒血清流行率较低的国家（成年普通人群中<5%），如美国、北欧和亚洲，感染主要涉及男同性恋者。在这一人群中，病毒传播似乎发生在性行为期间。在一些流行国家（成年普通人群中HHV-8血清流行率在10%-70%之间），如地中海盆地（意大利、希腊）和非洲（东非和中非），男性、女性和儿童都会被感染。在这些国家，HHV-8血清流行率随年龄增长而上升，通常在青春期结束前达到成人水平。在一般的流行人群中，病毒传播似乎发生在母婴之间和兄弟姐妹之间，而异性传播似乎主要涉及性传播疾病的高危人群。唾液是HHV-8的主要储存库。
