Pohl Nicola L
Department of Chemistry and the Plant Sciences Institute, 2756 Gilman Hall, Iowa State University, Ames, IA 50011-3111, USA.
Curr Opin Chem Biol. 2002 Dec;6(6):773-8. doi: 10.1016/s1367-5931(02)00360-5.
Polyketides are a large class of structurally diverse, biologically active natural products. Recent experiments add evidence that many of the enzymes involved in the biosynthesis of these natural products are intrinsically tolerant of nonnatural substrates. In addition, an increasing understanding of structure-function relationships in various enzyme-substrate systems is aiding efforts to begin engineering these proteins for even greater synthetic utility.
聚酮化合物是一大类结构多样、具有生物活性的天然产物。最近的实验进一步证明，参与这些天然产物生物合成的许多酶本质上能够耐受非天然底物。此外，对各种酶 - 底物系统中结构 - 功能关系的日益了解，有助于人们开始对这些蛋白质进行改造，以获得更大的合成效用。
