使用维替泊芬的光动力疗法诱发微小病变型肾病综合征。
Photodynamic therapy using verteporfin-induced minimal change nephrotic syndrome.
作者信息
Kang Shin W, Kang Shin J, Kim Hyun O, Nam Eun S, Lee Jin H, Koh Hyoung J
机构信息
Department of Internal Medicine, Institute of Kidney Disease, Yonsei University College of Medicine, Sodaemun-gu, Seoul, South Korea.
出版信息
Am J Ophthalmol. 2002 Dec;134(6):907-8. doi: 10.1016/s0002-9394(02)01752-x.
PURPOSE
To report a case of minimal change nephrotic syndrome (MCNS) after photodynamic therapy using verteporfin.
DESIGN
Interventional case report.
METHODS
After four cycles of photodynamic therapy, general weakness with generalized edema developed in an otherwise healthy 66-year-old woman, resulting in dyspnea and ascites. Urinalysis showed heavy proteinuria (4+) with decreased serum total protein and albumin, and increased total cholesterol levels, suggesting nephrotic syndrome. Renal biopsy and pathologic diagnosis were performed.
RESULTS
Renal biopsy revealed normal glomeruli and tubulointerstitium by light microscopy, with no immunoglobin or complement deposition. Transmission electron microscopy showed diffuse effacement of the foot processes of visceral epithelial cells, which is the characteristic finding of minimal change nephrotic syndrome.
CONCLUSIONS
We herein report a case of minimal change nephrotic syndrome after photodynamic therapy using verteporfin.
目的
报告一例使用维替泊芬进行光动力治疗后发生微小病变肾病综合征（MCNS）的病例。
设计
介入性病例报告。
方法
在四个周期的光动力治疗后，一名原本健康的66岁女性出现全身乏力伴全身性水肿，导致呼吸困难和腹水。尿液分析显示大量蛋白尿（4+），血清总蛋白和白蛋白降低，总胆固醇水平升高，提示肾病综合征。进行了肾活检和病理诊断。
结果
光镜下肾活检显示肾小球和肾小管间质正常，无免疫球蛋白或补体沉积。透射电子显微镜显示脏层上皮细胞足突弥漫性消失，这是微小病变肾病综合征的特征性表现。
结论
我们在此报告一例使用维替泊芬进行光动力治疗后发生微小病变肾病综合征的病例。
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