LeVeen H H, Wapnick S, Falk G, Olivas O, Bhat D, Gaurdre M, Patel M
Am J Surg. 1976 Jan;131(1):47-53. doi: 10.1016/0002-9610(76)90419-0.
The effect of antibiotic colon preparation on the tensile strength and morphologic appearance of colonic anastomoses has been investigated in dogs. Preparation with preoperative kanamycin did offer a slight benefit over mechanical bowel cleansing. The addition of erythromycin and kanamycin to the preoperative bowel preparation significantly (p less than 0.001) improved the mean tensile strengh of the healing colonic anastomosis. Continuation of erythromycin and kanamycin for one week postoperatively almost doubled the mean tensile strength of the healing anastomosis. Continuation of erythromycin without kanamycin in the postoperative period provided little protection over the preoperative administration of kanamycin and erythromycin. Histologic examination showed that erythromycin and kanamycin given during the pre- and postoperative period changed the mode of healing from that of secondary intention to healing by first intention. The findings support the concept that soilage of the peritoneal cavity at the time of elective colon surgery is not as important as leakage caused by poor anastomotic healing. Antibiotic bowel preparation with kanamycin and erythromycin improves the healing of colonic anastomoses.
在犬类动物中，已对抗生素肠道准备对结肠吻合口抗张强度和形态外观的影响进行了研究。术前使用卡那霉素进行准备确实比机械性肠道清洁略有优势。术前肠道准备中添加红霉素和卡那霉素显著（p小于0.001）提高了愈合中结肠吻合口的平均抗张强度。术后持续使用红霉素和卡那霉素一周，愈合中吻合口的平均抗张强度几乎翻倍。术后仅持续使用红霉素而不使用卡那霉素，相对于术前给予卡那霉素和红霉素几乎没有提供更多保护。组织学检查表明，术前和术后给予红霉素和卡那霉素使愈合方式从二期愈合转变为一期愈合。这些发现支持这样一个概念，即择期结肠手术时腹腔污染不如吻合口愈合不良导致的渗漏重要。用卡那霉素和红霉素进行抗生素肠道准备可改善结肠吻合口的愈合。
