Department of Surgery, University of Chicago, Pritzker School of Medicine, Chicago, Illinois, USA.
Surg Infect (Larchmt). 2023 Apr;24(3):265-270. doi: 10.1089/sur.2023.001.
The emergence of the gut microbiome as a complex ecosystem that plays a key role in human heath and disease has touched virtually every aspect of medical and surgical care. With the advent of next-generation technology to interrogate the microbiome at the level of its membership, community structure and production of metabolites, applying measures by which the gut microbiome can be manipulated to the advantage of both the patient and provider is now possible. Among the many proposed methods, the most practical and promising is dietary pre-habilitation of the gut microbiome prior to high-risk anastomotic surgery. In this review, we will outline the scientific rationale and molecular underpinning that support dietary pre-habilitation as a practical and deliverable method to prevent complications after high-risk anastomotic surgery.
肠道微生物组作为一个复杂的生态系统出现，在人类健康和疾病中发挥着关键作用，几乎触及了医疗和外科护理的各个方面。随着下一代技术的出现，可以在微生物组的成员、群落结构和代谢产物的产生水平上对其进行检测，现在可以应用控制肠道微生物组的措施，使患者和提供者都受益。在众多提出的方法中，最实用和最有前途的是在高风险吻合术之前对肠道微生物组进行饮食预适应。在这篇综述中，我们将概述支持饮食预适应作为一种预防高风险吻合术后并发症的实用和可行方法的科学依据和分子基础。
