Robertson Steven S, Dierker LeRoy J
Department of Human Development, Cornell University, Ithaca, NY 14853, USA.
Dev Psychobiol. 2003 Jan;42(1):9-16. doi: 10.1002/dev.10045.
Spontaneous fetal movement in the last third of human gestation is dominated by irregular oscillations on a scale of minutes (cyclic motility, CM). The core properties of these oscillations are stable during the third trimester of gestation in normal fetuses, but disrupted by poorly controlled maternal diabetes. Here we investigated whether fetal CM is linked to short-term instabilities in maternal glucose metabolism. The fetuses of 40 mothers with type I (n = 28) or gestational (n = 12) diabetes were studied one to six times between 27 and 40 postmenstrual weeks of gestation. Fetal movement and maternal blood glucose concentration were measured during two separate periods of fetal activity in each session. Fetal CM was quantified with spectral analysis. Early in the third trimester, changes in the rate of oscillation in fetal CM between the two periods of activity were inversely related to changes in maternal blood glucose levels. Fetal CM was unrelated to concurrent maternal blood glucose levels at any point in the third trimester. The pattern of results suggests that disruption of the temporal organization of spontaneous fetal motor activity in pregnancies complicated by maternal diabetes represents an acute response to fluctuations in the metabolic environment rather than an alteration of CM development.
在人类妊娠的最后三个月，胎儿的自发运动以分钟为尺度的不规则振荡为主（周期性运动，CM）。在正常胎儿的妊娠晚期，这些振荡的核心特性是稳定的，但在母亲糖尿病控制不佳时会受到干扰。在这里，我们研究了胎儿CM是否与母亲葡萄糖代谢的短期不稳定性有关。对40名患有I型糖尿病（n = 28）或妊娠期糖尿病（n = 12）的母亲的胎儿，在妊娠月经周期后的27至40周之间进行了一至六次研究。在每次检查的两个独立的胎儿活动期测量胎儿运动和母亲血糖浓度。用频谱分析对胎儿CM进行量化。在妊娠晚期早期，两个活动期之间胎儿CM振荡率的变化与母亲血糖水平的变化呈负相关。在妊娠晚期的任何时间点，胎儿CM与母亲的同期血糖水平无关。结果模式表明，在母亲糖尿病合并妊娠中，自发胎儿运动活动的时间组织破坏代表了对代谢环境波动的急性反应，而不是CM发育的改变。
