Cangiano J L, Ramirez-Muxó O, Ramirez-Gonzalez R, Trevino A, Campos J A
Arch Intern Med. 1976 Jan;136(1):17-23. doi: 10.1001/archinte.136.1.17.
Studies were undertaken in 33 uremic patients with or without hypertension, 11 normal subjects, and 15 essential hypertensive patients to assess cardiac hemodynamics, plasma volume, extracellular fluid volume, and peripheral renin levels. Cardiac output and intraarterial blood pressure were measured and peripheral vascular resistance index calculated. These studies suggest that uremic hypertension with normal renin values and hypervolemia is hemodynamically sustained by an increase in peripheral resistance rather than by an increased cardiac output. The renin angiotensin system plays a secondary role as compared to overexpansion in the genesis of hypertension in normoreninemic uremic hypertension.
对33例有或无高血压的尿毒症患者、11例正常受试者和15例原发性高血压患者进行了研究，以评估心脏血流动力学、血浆容量、细胞外液容量和外周肾素水平。测量心输出量和动脉内血压，并计算外周血管阻力指数。这些研究表明，肾素值正常且血容量过多的尿毒症性高血压在血流动力学上是由外周阻力增加而非心输出量增加维持的。与血容量过多相比，肾素 - 血管紧张素系统在正常肾素水平的尿毒症性高血压发病机制中起次要作用。
