Algeciras-Schimnich Alicia, Barnhart Bryan C, Peter Marcus E
The Ben May Institute for Cancer Research, University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA.
Curr Opin Cell Biol. 2002 Dec;14(6):721-6. doi: 10.1016/s0955-0674(02)00384-8.
Caspases are well known for their role in the execution of the apoptotic program by cleaving specific target proteins, leading to the dismantling of the cell, as well as for mediating cytokine maturation. Recent work has highlighted novel non-apoptotic activities of apoptotic caspases. These reports indicate that caspases are much more versatile enzymes than we originally expected. In addition to regulating cell survival and cytokine maturation, caspases may be involved in regulating cell differentiation, cell proliferation, spreading and receptor internalization.
半胱天冬酶因其在通过切割特定靶蛋白来执行凋亡程序从而导致细胞解体方面的作用以及介导细胞因子成熟而广为人知。最近的研究突出了凋亡性半胱天冬酶的新型非凋亡活性。这些报告表明，半胱天冬酶是比我们最初预期的更为多功能的酶。除了调节细胞存活和细胞因子成熟外，半胱天冬酶可能还参与调节细胞分化、细胞增殖、细胞铺展和受体内化。
