Zaitceva Victoria, Kopeina Gelina S, Zhivotovsky Boris
Faculty of Medicine, MV Lomonosov Moscow State University, 119991 Moscow, Russia.
Division of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, 17177 Stockholm, Sweden.
Cancers (Basel). 2021 Jul 22;13(15):3671. doi: 10.3390/cancers13153671.
For over 20 years, it has been a dogma that once the integrity of mitochondria is disrupted and proapoptotic proteins that are normally located in the intermembrane space of mitochondria appeared in the cytoplasm, the process of cell death becomes inevitable. However, it has been recently shown that upon removal of the death signal, even at the stage of disturbance in the mitochondria, cells can recover and continue to grow. This phenomenon was named anastasis. Here, we will critically discuss the present knowledge concerning the mechanisms of cell death reversal, or development of anastasis, methods for its detection, and what role signaling from different intracellular compartments plays in anastasis stimulation.
20多年来，一直存在这样一个信条：一旦线粒体的完整性被破坏，正常位于线粒体外膜间隙的促凋亡蛋白出现在细胞质中，细胞死亡过程就不可避免。然而，最近有研究表明，在去除死亡信号后，即使在线粒体受到干扰的阶段，细胞也可以恢复并继续生长。这种现象被称为复苏。在此，我们将批判性地讨论目前关于细胞死亡逆转机制或复苏发生机制的知识、其检测方法，以及来自不同细胞内区室的信号在复苏刺激中所起的作用。
