Malarkey W B, Johnson J C
Arch Intern Med. 1976 Jan;136(1):40-4.
Hyperprolactinemia was demonstrated in eight of nine patients with clinical evidence of pituitary tumors without acromegaly or Cushing syndrome. Hourly sampling for 24 hours disclosed elevation of serum prolactin concentrations, whereas, measurable serum growth hormone levels were found rarely. Although eight of these patients were hypersecreting prolactin, only four of them were lactating. Prolactin secretion was characterized by moderate hourly fluctuations of serum levels and absence or blunting of the normal sleep-related augmentation of secretion. Patients with the highest serum prolactin concentrations tended to have the largest pituitary tumors, as indicated by pneumoencephalography. In two patients followed-up with serum prolactin determinations after treatment, a fall in serum prolactin concentrations correlated with clinical improvement. Future study will hopefully establish the value of serum prolactin determinations in following tumor growth before and after pituitary ablative therapy.
在9例有垂体肿瘤临床证据但无肢端肥大症或库欣综合征的患者中，有8例出现高催乳素血症。24小时每小时采样显示血清催乳素浓度升高，而很少发现可测量的血清生长激素水平。虽然这些患者中有8例催乳素分泌过多，但其中只有4例泌乳。催乳素分泌的特点是血清水平每小时有中度波动，且正常的与睡眠相关的分泌增加不存在或减弱。气脑造影显示，血清催乳素浓度最高的患者往往有最大的垂体肿瘤。在2例治疗后随访血清催乳素测定的患者中，血清催乳素浓度下降与临床改善相关。未来的研究有望确定血清催乳素测定在垂体切除术前和术后跟踪肿瘤生长方面的价值。
