Kornfeld M, Buckmann M T, McClellan G
Acta Neuropathol. 1981;53(1):1-5. doi: 10.1007/BF00697177.
Morphometric analysis of secretory granules was performed in 16 chromophobe adenomas: seven undifferentiated cell adenomas (group A), two of which were accompanied by mild hyperprolactinemia and nine prolactin cell sparsely granulated adenomas (group B), all associated with hyperprolactinemia. The results of morphometry were correlated with levels of prolactin in tumor and serum. The range of granule diameters was similar in both groups but granule size frequency was different resulting in a characteristic histogram for each group. Poor relationship existed between granule mean diameter and prolactin in tissue of the group B. In the same group there was virtually no linear relationship between serum prolactin on one side and granule mean diameter, granule density or tissue prolactin on the other. Also in the group B a paradoxical inverse relationship was found between granule density and tumor prolactin. Apparently, in prolactin cell adenoma a sizable part of hormone is located outside of mature secretory granules. An abundance of immature granules, misplaced exocytosis, crinophagia or defect in packaging of the hormone could all explain this paradox but the last possibility seems most plausible.
对16例嫌色性腺瘤进行了分泌颗粒的形态计量分析：7例未分化细胞腺瘤（A组），其中2例伴有轻度高催乳素血症，9例催乳素细胞稀疏颗粒性腺瘤（B组），均伴有高催乳素血症。形态计量结果与肿瘤和血清中的催乳素水平相关。两组颗粒直径范围相似，但颗粒大小频率不同，导致每组有特征性的直方图。B组组织中颗粒平均直径与催乳素之间关系不佳。在同一组中，血清催乳素与颗粒平均直径、颗粒密度或组织催乳素之间几乎没有线性关系。同样在B组中，发现颗粒密度与肿瘤催乳素之间存在矛盾的负相关关系。显然，在催乳素细胞腺瘤中，相当一部分激素位于成熟分泌颗粒之外。大量未成熟颗粒、错位的胞吐作用、噬分泌现象或激素包装缺陷都可以解释这一矛盾，但最后一种可能性似乎最合理。
