Ginsburg Hagai
Dept of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem, 91904, Jerusalem, Israel.
Trends Parasitol. 2002 Nov;18(11):483-6. doi: 10.1016/s1471-4922(02)02350-4.
Intraerythrocytic Plasmodium parasites depend on glycolysis for energy production. The stoichiometric amounts of lactate and protons produced are efficiently removed by a lactate:H(+) symporter. However, inhibition of recently identified plasma-membrane proton pumps result in acidification, suggesting additional mechanism(s) for proton generation. This article attempts to integrate the knowledge on the metabolic generation of protons and their disposal in the regulation of parasite cytosolic pH, and suggests additional roles for the various proton pumps that act in the parasite membrane.
红细胞内的疟原虫依赖糖酵解来产生能量。所产生的化学计量的乳酸和质子通过乳酸：H(+)同向转运体被有效清除。然而，对最近鉴定出的质膜质子泵的抑制会导致酸化，这表明存在其他质子产生机制。本文试图整合关于质子代谢产生及其在寄生虫细胞质pH调节中的处置的知识，并提出在寄生虫膜中起作用的各种质子泵的其他作用。
