Albrecht Ester W J A, Stegeman Coen A, Heeringa Peter, Henning Rob H, van Goor Harry
Department of Pathology and Laboratory Medicine, University Hospital Groningen, Groningen, The Netherlands.
J Pathol. 2003 Jan;199(1):8-17. doi: 10.1002/path.1250.
Nitric oxide is a versatile molecule, with its actions ranging from haemodynamic regulation to anti-proliferative effects on vascular smooth muscle cells. Nitric oxide is produced by the nitric oxide synthases, endothelial NOS (eNOS), neural NOS (nNOS), and inducible NOS (iNOS). Constitutively expressed eNOS produces low concentrations of NO, which is necessary for a good endothelial function and integrity. Endothelial derived NO is often seen as a protective agent in a variety of diseases. This review will focus on the potential protective role of eNOS. We will discuss recent data derived from studies in eNOS knockout mice and other experimental models. Furthermore, the role of eNOS in human diseases is described and possible therapeutic intervention strategies will be discussed.
一氧化氮是一种多功能分子，其作用范围从血流动力学调节到对血管平滑肌细胞的抗增殖作用。一氧化氮由一氧化氮合酶产生，包括内皮型一氧化氮合酶（eNOS）、神经型一氧化氮合酶（nNOS）和诱导型一氧化氮合酶（iNOS）。组成性表达的eNOS产生低浓度的NO，这对于良好的内皮功能和完整性是必需的。内皮源性NO在多种疾病中常被视为一种保护剂。本综述将聚焦于eNOS的潜在保护作用。我们将讨论来自eNOS基因敲除小鼠及其他实验模型研究的最新数据。此外，还将描述eNOS在人类疾病中的作用，并探讨可能的治疗干预策略。
