Kim Taeseong, Suzuki Masahiko, Ohtsuki Chikara, Masuda Kimihiko, Tamai Hiroshi, Watanabe Eiichirou, Osaka Akiyoshi, Moriya Hideshige
Department of Orthopaedic Surgery, Graduate School of Medicine, Chiba University 1-8-1, Inohana, Chuo-ku, Chiba 260-8677, Japan.
J Biomed Mater Res B Appl Biomater. 2003 Jan 15;64(1):19-26. doi: 10.1002/jbm.b.10469.
A tight fixation between bone and implant materials is of great importance for a successful outcome of procedures such as total knee arthroplasty (TKA) and total hip arthroplasty (THA). Surface modification of titanium metal and titanium alloy is one of the attractive methods to improve the biological affinity of orthopedic prostheses. Recent studies reported that titanium substrates were provided with bone-bonding ability, that is, osteoconductivity, through a chemical treatment with hydrogen peroxide solution containing tantalum chloride. The present study investigated the histological and mechanical effects of such treatment of the surface of titanium fiber mesh. Titanium alloy rods of 7.6 x 7.6 x 20 mm that had a titanium fiber mesh of 250 microm were implanted bilaterally into the distal aspect of the femur of adult beagle dogs. At 3, 5, and 8 weeks after implantation, the rods were removed to examine their bonding strength and histological compatibility with bone. Bonding strength was evaluated by the pull-out test. The bonding strength of the treated specimen with bone increased with time, and was faster than that of untreated specimens. At 8 weeks postoperative, the bonding strength of both the treated and untreated specimens became almost equal. The amount of newly formed bone on and in the titanium fiber mesh was significantly increased by the chemical treatment (p<0.05). The rate of bone formation in the fiber mesh was accelerated after chemical treatment. These results indicated that the surface treatment enhanced bone formation in the initial stage thank to the osteoconductive property of the titanium fiber mesh conferred by the chemical treatment so that faster bonding strength was achieved. Surface treatment providing titanium mesh with osteoconductivity has the advantages of the fast healing and tight bonding for prostheses in TKA and THA.
骨骼与植入材料之间的紧密固定对于全膝关节置换术（TKA）和全髋关节置换术（THA）等手术的成功结果至关重要。钛金属和钛合金的表面改性是提高骨科假体生物亲和力的一种有吸引力的方法。最近的研究报告称，通过用含氯化钽的过氧化氢溶液进行化学处理，钛基底具有了骨结合能力，即骨传导性。本研究调查了这种对钛纤维网表面处理的组织学和力学效应。将带有250微米钛纤维网的7.6×7.6×20毫米钛合金棒双侧植入成年比格犬股骨远端。在植入后3、5和8周，取出棒材以检查其与骨的结合强度和组织学相容性。通过拔出试验评估结合强度。经处理的标本与骨的结合强度随时间增加，且比未处理的标本增加得更快。术后8周，处理过的和未处理的标本的结合强度几乎相等。化学处理显著增加了钛纤维网上和网内新形成骨的量（p<0.05）。化学处理后纤维网内的骨形成速率加快。这些结果表明，由于化学处理赋予钛纤维网骨传导性，表面处理在初始阶段增强了骨形成，从而实现了更快的结合强度。为钛网提供骨传导性的表面处理具有在TKA和THA中假体愈合快和结合紧密的优点。
