Rey E, Díaz-Rubio M
Digestive Service, Hospital Clínico San Carlos, Madrid, Spain.
Rev Esp Enferm Dig. 2002 May;94(5):247-58.
To evaluate the prevalence of rectal hypersensitivity in our irritable bowel syndrome (IBS) patients, the relationship of hypersensitivity to rectal distensibility and the differences in sensitivity among clinical subgroups of IBS.
18 healthy subjects and 56 IBS patients (Rome-II criteria; 22 diarrhea-predominant, 15 constipation-predominant and 19 alternating). Rectal sensitivity and distensibility were studied by isobaric phasic distension of a poliethilene bag with a barostat.
IBS patients showed a lower threshold for discomfort, pain and maximum tolerate distension, without any differences in rectal distensibility. 64% of IBS patients were hypersensitive. 89% of patients with alternating IBS were hypersensitive while only 68% and 26% of patients with diarrhea-predominant IBS and constipation-predominant IBS, respectively, were. There were no differences in rectal distensibility between hypersensitive and normosensitive patients.
64% of our IBS patients show rectal hypersensitivity, apparently not related to rectal distensibility. Hypersensitivity is mostly found in alternating IBS patients, and rare in constipation-predominant IBS.
评估肠易激综合征（IBS）患者中直肠超敏反应的患病率、超敏反应与直肠扩张性的关系以及IBS临床亚组之间敏感性的差异。
18名健康受试者和56名IBS患者（符合罗马II标准；22名腹泻型、15名便秘型和19名混合型）。采用带有恒压器的聚乙烯袋等压相性扩张法研究直肠敏感性和扩张性。
IBS患者在不适、疼痛和最大耐受扩张方面的阈值较低，直肠扩张性无差异。64%的IBS患者存在超敏反应。89%的混合型IBS患者存在超敏反应，而腹泻型IBS患者和便秘型IBS患者的这一比例分别仅为68%和26%。超敏患者与正常敏感患者的直肠扩张性无差异。
我们的IBS患者中有64%存在直肠超敏反应，显然与直肠扩张性无关。超敏反应在混合型IBS患者中最为常见，在便秘型IBS患者中罕见。
